Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance

被引：53

作者：

Abraham, Ioana ^{[1
]}

El Sayed, Khalid ^{[2
]}

Chen, Zhe-Sheng ^{[1
]}

Guo, Huiqin ^{[3
]}

机构：

[1] St Johns Univ, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, Jamaica, NY 11439 USA

[2] Univ Louisiana, Coll Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71201 USA

[3] Peking Union Med Coll Hosp, Dept Thorac Surg, Beijing 100730, Peoples R China

来源：

MARINE DRUGS | 2012年 / 10卷 / 10期

关键词：

marine natural products; multidrug resistance; ABC transporters; SOFT-TISSUE SARCOMAS; P-GLYCOPROTEIN; PHASE-II; NATURAL-PRODUCTS; PROTEIN-KINASE; ERIBULIN MESYLATE; DRUG-RESISTANCE; STEROL ACETATE; AGOSTEROL-A; BRYOSTATIN;

D O I：

10.3390/md10102312

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The resistance of tumor cells to a broad range of anticancer agents continues to be a problem for the success of cancer chemotherapy. Multidrug resistance (MDR) is due in part to three drug transporter proteins: ABCB1/P-glycoprotein (P-gp), ABCC1/multidrug resistance protein 1 (MRP1) and ABCG2/breast cancer resistance protein (BCRP). These transporters are part of the ATP-binding cassette (ABC) superfamily, whose members function as ATP-dependent drug-efflux pumps. Their activity can be blocked by various drugs such as verapamil (calcium channel blocker) and cyclosporin A (immunosuppressive agent), etc. These compounds are called MDR modulators or reversals. This review highlights several marine natural products with reversal effect on multidrug resistance in cancer, including agosterol A, ecteinascidin 743, sipholane triterpenoids, bryostatin 1, and welwitindolinones.

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页码：2312 / 2321

页数：10

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