Epigenetic therapy of cancer: past, present and future

被引：1034

作者：

Yoo, CB

Jones, PA

机构：

[1] Univ So Calif, USC Norris Comprehens Canc Ctr, Dept Urol, Los Angeles, CA 90089 USA

[2] Univ So Calif, Dept Biochem & Mol Biol, Keck Sch Med, Los Angeles, CA 90089 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 01期

关键词：

D O I：

10.1038/nrd1930

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The initiation and progression of cancer is controlled by both genetic and epigenetic events. Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations are potentially reversible, allowing the malignant cell population to revert to a more normal state. With the advent of numerous drugs that target specific enzymes involved in the epigenetic regulation of gene expression, the utilization of epigenetic targets is emerging as an effective and valuable approach to chemotherapy as well as chemoprevention of cancer.

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收藏

页码：37 / 50

页数：14

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