Molecular analysis of a new splice variant of the human melanocortin-1 receptor

被引：54

作者：

Tan, CP ^{[1
]}

McKee, KK ^{[1
]}

Weinberg, DH ^{[1
]}

MacNeil, T ^{[1
]}

Palyha, OC ^{[1
]}

Feighner, SD ^{[1
]}

Hreniuk, DL ^{[1
]}

Van der Ploeg, LHT ^{[1
]}

MacNeil, DJ ^{[1
]}

Howard, AD ^{[1
]}

机构：

[1] Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA

来源：

FEBS LETTERS | 1999年 / 451卷 / 02期

关键词：

melanocortin; G-protein-coupled receptor; pigmentation;

D O I：

10.1016/S0014-5793(99)00525-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The primary hormonal regulator of pigmentation is melanocyte stimulating hormone derived from proopiomelanocortin by proteolytic processing. The melanocortin-1 receptor sen es a key role in the regulation of pigmentation, We describe the identification of the first intron within a melanocortin receptor. A new melanocortin-1 receptor isoform, generated by alternative mRNA splicing, encodes an additional 65 amino acids at the predicted intracellular, C-terminal tail of the melanocortin-1 receptor, When expressed in heterologous cells, the new spliced form of the melanocortin-1 receptor (melanocortin-1 receptor B) appears pharmacologically similar to the non-spliced melanocortin-1 receptor, Melanocortin-1 receptor B is expressed in testis, fetal heart and melanomas, (C) 1999 Federation of European Biochemical Societies.

引用

页码：137 / 141

页数：5

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