Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration

被引：45

作者：

Varon, David ^{[1
]}

Hayon, Yael ^{[1
]}

Dashevsky, Olga ^{[1
]}

Shai, Ela ^{[1
]}

机构：

[1] Hadassah Univ Hosp, Dept Hematol, Coagulat Unit, IL-91120 Jerusalem, Israel

来源：

THROMBOSIS RESEARCH | 2012年 / 130卷

关键词：

INDUCE ANGIOGENESIS;

D O I：

10.1016/j.thromres.2012.08.289

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelets play a major role in hemostasis, but are also involved in vascular biology processes such as angiogenesis and tumor metastasis. Activated platelets release many proteins favoring wound healing and promoting angiogenesis. Microparticles (MP) are small plasma membrane vesicles shed from cells upon their activation or apoptosis. Platelet-derived microparticles (PMP) constitute the majority of the pool of MP circulating in the blood. PMP express and may transfer functional receptors, stimulate the release of cytokines, activate intracellular signaling pathways, promote angiogenesis, and are involved in tissue regeneration and cancer metastasis. We investigated the effect of PMP on cancer cells metastasis and their potential beneficial effect in an ischemic stroke model. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：S98 / S99

页数：2

共 6 条

[1] Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization [J].

Brill, A ;

Dashevsky, O ;

Rivo, J ;

Gozal, Y ;

Varon, D .

CARDIOVASCULAR RESEARCH, 2005, 67 (01) :30-38

[2] Platelet-derived microparticles promote invasiveness of prostate cancer cells via upregulation of MMP-2 production [J].

Dashevsky, Olga ;

Varon, David ;

Brill, Alexander .

INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (08) :1773-1777

[3] Platelet Microparticles Induce Angiogenesis and Neurogenesis after Cerebral Ischemia [J].

Hayon, Yael ;

Dashevsky, Olga ;

Shai, Ela ;

Brill, Alex ;

Varon, David ;

Leker, Ronen R. .

CURRENT NEUROVASCULAR RESEARCH, 2012, 9 (03) :185-192

[4] Platelet Microparticles Promote Neural Stem Cell Proliferation, Survival and Differentiation [J].

Hayon, Yael ;

Dashevsky, Olga ;

Shai, Ela ;

Varon, David ;

Leker, Ronen R. .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2012, 47 (03) :659-665

[5] Platelet microparticles induce angiogenesis in vitro [J].

Kim, HK ;

Song, KS ;

Chung, JH ;

Lee, KR ;

Lee, SN .

BRITISH JOURNAL OF HAEMATOLOGY, 2004, 124 (03) :376-384

[6]

Shai E., 2012, J PROTEOMICS

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