Tumor immune microenvironment characterization and response to anti-PD-1 therapy

被引：79

作者：

Santarpia, Mariacarmela ^{[1
]}

Karachaliou, Niki ^{[2
]}

机构：

[1] Univ Messina, Human Pathol Dept, Med Oncol Unit, I-98122 Messina, Italy

[2] Quiron Dexeus Univ Hosp, Dr Rosell Oncol Inst, Translat Res Unit, Barcelona 08028, Spain

来源：

CANCER BIOLOGY & MEDICINE | 2015年 / 12卷 / 02期

关键词：

PD-L1; EXPRESSION; BLOCKADE; NIVOLUMAB; CHECKPOINTS; ANTIBODY; SAFETY; B7-H1;

D O I：

10.7497/j.issn.2095-3941.2015.0022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

[No abstract available]

引用

页码：74 / 78

页数：5

共 20 条

[1]

Antonia SJ, 2013, J THORAC ONCOL, V8, pS907

[2]

Effects of MAPK and PI3K Pathways on PD-L1 Expression in Melanoma [J].

Atefi, Mohammad ;

Avramis, Earl ;

Lassen, Amanda ;

Wong, Deborah J. L. ;

Robert, Lidia ;

Foulad, David ;

Cerniglia, Michael ;

Titz, Bjoern ;

Chodon, Thinle ;

Graeber, Thomas G. ;

Comin-Anduix, Begonya ;

Ribas, Antoni .

CLINICAL CANCER RESEARCH, 2014, 20 (13) :3446-3457

[3]

Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines [J].

Butt, A. Q. ;

Mills, K. H. G. .

ONCOGENE, 2014, 33 (38) :4623-4631

[4]

Clinical impact of programmed cell death ligand 1 expression in colorectal cancer [J].

Droeser, Raoul A. ;

Hirt, Christian ;

Viehl, Carsten T. ;

Frey, Daniel M. ;

Nebiker, Christian ;

Huber, Xaver ;

Zlobec, Inti ;

Eppenberger-Castori, Serenella ;

Tzankov, Alexander ;

Rosso, Raffaele ;

Zuber, Markus ;

Muraro, Manuele Giuseppe ;

Amicarella, Francesca ;

Cremonesi, Eleonora ;

Heberer, Michael ;

Iezzi, Giandomenica ;

Lugli, Alessandro ;

Terracciano, Luigi ;

Sconocchia, Giuseppe ;

Oertli, Daniel ;

Spagnoli, Giulio C. ;

Tornillo, Luigi .

EUROPEAN JOURNAL OF CANCER, 2013, 49 (09) :2233-2242

[5]

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation [J].

Freeman, GJ ;

Long, AJ ;

Iwai, Y ;

Bourque, K ;

Chernova, T ;

Nishimura, H ;

Fitz, LJ ;

Malenkovich, N ;

Okazaki, T ;

Byrne, MC ;

Horton, HF ;

Fouser, L ;

Carter, L ;

Ling, V ;

Bowman, MR ;

Carreno, BM ;

Collins, M ;

Wood, CR ;

Honjo, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (07) :1027-1034

[6]

Overall Survival and PD-L1 Expression in Metastasized Malignant Melanoma [J].

Gadiot, Jules ;

Hooijkaas, Anna I. ;

Kaiser, Andrew D. M. ;

van Tinteren, Harm ;

van Boven, Hester ;

Blank, Christian .

CANCER, 2011, 117 (10) :2192-2201

[7]

Grosso J, 2013, J CLIN ONCOL, V31

[8]

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients [J].

Herbst, Roy S. ;

Soria, Jean-Charles ;

Kowanetz, Marcin ;

Fine, Gregg D. ;

Hamid, Omid ;

Gordon, Michael S. ;

Sosman, Jeffery A. ;

McDermott, David F. ;

Powderly, John D. ;

Gettinger, Scott N. ;

Kohrt, Holbrook E. K. ;

Horn, Leora ;

Lawrence, Donald P. ;

Rost, Sandra ;

Leabman, Maya ;

Xiao, Yuanyuan ;

Mokatrin, Ahmad ;

Koeppen, Hartmut ;

Hegde, Priti S. ;

Mellman, Ira ;

Chen, Daniel S. ;

Hodi, F. Stephen .

NATURE, 2014, 515 (7528) :563-+

[9]

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1) [J].

Marzec, Michal ;

Zhang, Qian ;

Goradia, Ami ;

Raghunath, Puthiyaveettil N. ;

Liu, Xiaobin ;

Paessler, Michele ;

Wang, Hong Yi ;

Wysocka, Maria ;

Cheng, Mangeng ;

Ruggeri, Bruce A. ;

Wasik, Mariusz A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (52) :20852-20857

[10]

High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation [J].

Mu, Chuan-Yong ;

Huang, Jian-An ;

Chen, Ying ;

Chen, Cheng ;

Zhang, Xue-Guang .

MEDICAL ONCOLOGY, 2011, 28 (03) :682-688

← 1 2 →