Reconstruction and Simulation of Neocortical Microcircuitry

被引：905

作者：

Markram, Henry ^{[1
,2
]}

Muller, Eilif ^{[1
]}

Ramaswamy, Srikanth ^{[1
]}

Reimann, Michael W. ^{[1
]}

Abdellah, Marwan ^{[1
]}

Sanchez, Carlos Aguado ^{[1
]}

Ailamaki, Anastasia ^{[18
]}

Alonso-Nanclares, Lidia ^{[6
,7
,8
]}

Antille, Nicolas ^{[1
]}

Arsever, Selim ^{[1
]}

Kahou, Guy Antoine Atenekeng ^{[1
]}

Berger, Thomas K. ^{[2
]}

Bilgili, Ahmet ^{[1
]}

Buncic, Nenad ^{[1
]}

Chalimourda, Athanassia ^{[1
]}

Chindemi, Giuseppe ^{[1
]}

Courcol, Jean-Denis ^{[1
]}

Delalondre, Fabien ^{[1
]}

Delattre, Vincent ^{[2
]}

Druckmann, Shaul ^{[4
,5
]}

Dumusc, Raphael ^{[1
]}

Dynes, James ^{[1
]}

Eilemann, Stefan ^{[1
]}

Gal, Eyal ^{[4
]}

Gevaert, Michael Emiel ^{[1
]}

Ghobril, Jean-Pierre ^{[2
]}

Gidon, Albert ^{[3
]}

Graham, Joe W. ^{[1
]}

Gupta, Anirudh ^{[2
]}

Haenel, Valentin ^{[1
]}

Hay, Etay ^{[3
,4
]}

Heinis, Thomas ^{[1
,18
,19
]}

Hernando, Juan B. ^{[9
]}

Hines, Michael ^{[14
]}

Kanari, Lida ^{[1
]}

Keller, Daniel ^{[1
]}

Kenyon, John ^{[1
]}

Khazen, Georges ^{[1
]}

Kim, Yihwa ^{[1
]}

King, James G. ^{[1
]}

Kisvarday, Zoltan ^{[15
]}

Kumbhar, Pramod ^{[1
]}

Lasserre, Sebastien ^{[1
,17
]}

Le Be, Jean-Vincent ^{[2
]}

Magalhaes, Bruno R. C. ^{[1
]}

Merchan-Perez, Angel ^{[6
,7
,8
]}

Meystre, Julie ^{[2
]}

Morrice, Benjamin Roy ^{[1
]}

Muller, Jeffrey ^{[1
]}

Munoz-Cespedes, Alberto ^{[6
,7
,8
]}

机构：

[1] EPFL, Blue Brain Project, CH-1202 Geneva, Switzerland

[2] EPFL, Brain Mind Inst, Lab Neural Microcircuitry, CH-1015 Geneva, Switzerland

[3] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Neurobiol, IL-91904 Jerusalem, Israel

[4] Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-91904 Jerusalem, Israel

[5] Howard Hughes Med Inst, Ashburn, VA 20147 USA

[6] Univ Politecn Madrid, Ctr Tecnol Biomed, Lab Cajal Circuitos Corticales, Madrid 28223, Spain

[7] Inst Cajal CSIC, Madrid 28002, Spain

[8] CIBERNED, Madrid 28002, Spain

[9] Univ Politecn Madrid, Ctr Supercomp & Visualizac Madrid, CeSViMa, Madrid 28223, Spain

[10] Univ Rey Juan Carlos, Modeling & Virtual Real Grp, Madrid 28933, Spain

[11] Wenzhou Med Coll, Key Lab Visual Sci, Wenzhou 325003, Peoples R China

[12] Wenzhou Med Coll, Natl Minist Hlth, Sch Optometry & Opthalmol, Wenzhou 325003, Peoples R China

[13] Tufts Univ, Genesys Res Inst, Caritas St Elizabeths Med Ctr, Boston, MA 02111 USA

[14] Yale Univ, Dept Neurobiol, New Haven, CT 06510 USA

[15] Neurosci Res Grp, MTA Debreceni Egyet, H-4032 Debrecen, Hungary

[16] Univ Nottingham, Sch Life Sci, Nottingham NG7 2UH, England

[17] Ecole Polytech Fed Lausanne, Lab Informat & Visualisat, CH-1015 Lausanne, Switzerland

[18] Ecole Polytech Fed Lausanne, Data Intens Applicat & Syst Lab, CH-1015 Lausanne, Switzerland

[19] Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England

[20] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

来源：

CELL | 2015年 / 163卷 / 02期

关键词：

RAT SOMATOSENSORY CORTEX; LAYER-5 PYRAMIDAL NEURONS; PARVALBUMIN-POSITIVE INTERNEURONS; TRANSMITTER RELEASE MODULATION; DUAL INTRACELLULAR-RECORDINGS; PARALLEL NETWORK SIMULATIONS; CORTICAL NONPYRAMIDAL CELLS; GENE-EXPRESSION PROFILES; MOUSE BARREL CORTEX; ACTIVITY IN-VIVO;

D O I：

10.1016/j.cell.2015.09.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 +/- 0.01 mm(3) containing similar to 31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morphoelectrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form similar to 8 million connections with similar to 37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies.

引用

页码：456 / 492

页数：37

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