Good Laboratory Practice Preventing Introduction of Bias at the Bench

被引：214

作者：

Macleod, Malcolm R. ^{[1
]}

Fisher, Marc ^{[2
]}

O'Collins, Victoria ^{[3
,4
]}

Sena, Emily S. ^{[1
,3
,4
]}

Dirnagl, Ulrich ^{[5
,6
]}

Bath, Philip M. W. ^{[7
]}

Buchan, Alistair ^{[8
]}

van der Worp, H. Bart ^{[9
]}

Traystman, Richard ^{[10
]}

Minematsu, Kazuo ^{[11
]}

Donnan, Geoffrey A. ^{[3
,4
]}

Howells, David W. ^{[3
,4
]}

机构：

[1] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh EH8 9YL, Midlothian, Scotland

[2] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA

[3] Natl Stroke Res Inst, Melbourne, Vic, Australia

[4] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

[5] Charite Dept Expt Neurol, Berlin, Germany

[6] Ctr Stroke Res, Berlin, Germany

[7] Univ Nottingham, Stroke Trials Unit, Nottingham NG7 2RD, England

[8] John Radcliffe Hosp, Nuffield Dept Med, Acute Stroke Program, Oxford OX3 9DU, England

[9] Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Neurol, Utrecht, Netherlands

[10] Univ Colorado Denver, Aurora, CO USA

[11] Natl Cardiovasc Ctr, Dept Med, Cerebrovasc Div, Osaka, Japan

来源：

STROKE | 2009年 / 40卷 / 03期

关键词：

animal models; basic science; drug trials; education; experimental; outcomes; preventing bias; translational research; RANDOMIZED CONTROLLED-TRIALS; ACUTE STROKE TRIALS; CONSORT STATEMENT; QUALITY; METAANALYSIS; IMPROVE; DRUGS;

D O I：

10.1161/STROKEAHA.108.525386

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose - As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review - Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Conclusions - Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke. (Stroke. 2009; 40: e50-e52.)

引用

页码：E50 / E52

页数：3

共 14 条

[1] The revised CONSORT statement for reporting randomized trials: Explanation and elaboration [J].

Altman, DG ;

Schulz, KF ;

Moher, D ;

Egger, M ;

Davidoff, F ;

Elbourne, D ;

Gotzsche, PC ;

Lang, T .

ANNALS OF INTERNAL MEDICINE, 2001, 134 (08) :663-694

[2] Quality of full and final publications reporting acute stroke trials - A systematic review [J].

Bath, FJ ;

Owen, VE ;

Bath, PMW .

STROKE, 1998, 29 (10) :2203-2210

[3] Improving the quality of reporting of randomized controlled trials - The CONSORT statement [J].

Begg, C ;

Cho, M ;

Eastwood, S ;

Horton, R ;

Moher, D ;

Olkin, I ;

Pitkin, R ;

Rennie, D ;

Schulz, KF ;

Simel, D ;

Stroup, DF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (08) :637-639

[4] Empirical evidence of bias in the design of experimental stroke studies - A metaepidemiologic approach [J].

Crossley, Nicolas A. ;

Sena, Emily ;

Goehler, Jos ;

Horn, Jannekke ;

van der Worp, Bart ;

Bath, Philip M. W. ;

Macleod, Malcolm ;

Dirnagl, Ulrich .

STROKE, 2008, 39 (03) :929-934

[5] Bench to bedside: the quest for quality in experimental stroke research [J].

Dirnagl, Ulrich .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2006, 26 (12) :1465-1478

[6] Recommendations for standards regarding preclinical neuroprotective and restorative drug development [J].

Feinklestein, SP ;

Fisher, M ;

Furland, AJ ;

Goldstein, LB ;

Gorelick, PB ;

Kaste, M ;

Lees, KR ;

Traystman, RJ ;

Albers, GW ;

Anwer, UE ;

Ashwood, T ;

Barone, FC ;

Basta, SL ;

Bogousslavsky, J ;

Buchan, AM ;

Cady, WJ ;

Chan, PH ;

Clemens, JA ;

Cox, BF ;

Craddock, RE ;

Cramer, SC ;

del Zoppo, GJ ;

Dielrich, WD ;

Elliott, P ;

Faden, AI ;

Feuerstein, GZ ;

Ginsberg, MD ;

Gold, M ;

Greene, WL ;

Hall, ED ;

Hsu, CY ;

Hunter, AJ ;

Lai, M ;

Lesko, LM ;

Levy, DE ;

Li, FH ;

Locke, KW ;

Lodge, D ;

Lowe, D ;

Marcoux, FW ;

McCulloch, J ;

McDermott, J ;

Meibach, R ;

Messersmith, EK ;

Moseley, M ;

Moskowitz, MA ;

Mueller, AL ;

Munro, F ;

Nudo, RJ ;

Oeda, J .

STROKE, 1999, 30 (12) :2752-2758

[7] WHY DO ALL DRUGS WORK IN ANIMALS BUT NONE IN STROKE PATIENTS .2. NEUROPROTECTIVE THERAPY [J].

GROTTA, J .

JOURNAL OF INTERNAL MEDICINE, 1995, 237 (01) :89-94

[8] Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke [J].

Macleod, MR ;

O'Collins, T ;

Horky, LL ;

Howells, DW ;

Donnan, GA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (06) :713-721

[9]

MACLEOD MR, 2008, STROKE IN PRESS, V39

[10] 1,026 experimental treatments in acute stroke [J].

O'Collins, VE ;

Macleod, MR ;

Donnan, GA ;

Horky, LL ;

van der Worp, BH ;

Howells, DW .

ANNALS OF NEUROLOGY, 2006, 59 (03) :467-477

← 1 2 →