A simple, convenient, general procedure for the synthesis of 2-alkyn-1-ylboronates

被引：11

作者：

Brown, HC

Roy, CD

Soundararajan, R

机构：

[1] H. C. Brown R. B. Wetherill Labs. C., Purdue University, West Lafayette

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(96)02412-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Representative 2-alkyn-1-ylboronates have been synthesized in good to excellent yields using the reaction of the newly available diisopropyl iodomethylboronate with alkynyllithiums generated in situ. Comparable yields are obtained from both acyclic and cyclic boronates. However, 2-(iodomethyl)-1,3,2-dioxa-4,4,5,5-tetramethylborolane gave superior yields with a wide variety of alkynyllithiums. This procedure offers a simple and convenient alternative route to existing methodologies in terms of the milder reaction condition and the ease of the operation. (C) 1997, Elsevier Science Ltd.

引用

页码：765 / 768

页数：4

共 12 条

[1] 9-ALLENYL-9-BBN - A NEW REAGENT FOR THE EFFICIENT ALLENYLBORATION OF CARBONYL-COMPOUNDS PRODUCING THE HOMOPROPARGYLIC ALCOHOLS IN HIGH-PURITY AND YIELD [J].