Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis

被引：42

作者：

McLeod, R

Khan, AR

Noble, GA

Latkany, P

Jalbrzikowski, J

Boyer, K

机构：

[1] Univ Chicago, Dept Ophthalmol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA

[4] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[5] Univ Chicago, Dept Committees Immunol, Chicago, IL 60637 USA

[6] Univ Chicago, Dept Mol & Med Genet, Chicago, IL 60637 USA

[7] Michael Reese Hosp & Med Ctr, Dept Med, Chicago, IL 60616 USA

[8] Univ Chicago, Dept Ophthalmol, Chicago, IL 60637 USA

[9] Rush Univ, Med Ctr, Dept Pediat, Div Pediat Infect Dis, Chicago, IL 60612 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2006年 / 25卷 / 03期

关键词：

drug rash with eosinophilia and systemic symptoms (DRESS) syndrome; hypersensitivity syndrome; Toxoplasma gondii; sulfadiazine;

D O I：

10.1097/01.inf.0000202070.59190.9a

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines. Symptoms resolved when systemic corticosteroids were administered. This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.

引用

页码：270 / 272

页数：3

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