Listeria monocytogenes infection in pregnant guinea pigs is associated with maternal liver necrosis, a decrease in maternal serum TNF-α concentrations, and an increase in placental apoptosis

被引：12

作者：

Irvin, Elizabeth Ann ^{[1
,2
]}

Williams, Denita ^{[1
,2
]}

Voss, Kenneth A. ^{[2
,3
]}

Smith, Mary Alice ^{[1
,2
]}

机构：

[1] Univ Georgia, Dept Environm Hlth Sci, Interdisciplinary Toxicol Program, Athens, GA 30606 USA

[2] Univ Georgia, Coll Agr & Environm Sci, Ctr Food Safety, Athens, GA 30606 USA

[3] USDA ARS, Toxicol & Mycotoxin Res Unit, Athens, GA 30613 USA

来源：

REPRODUCTIVE TOXICOLOGY | 2008年 / 26卷 / 02期

基金：

美国农业部;

关键词：

Listeria monocytogenes; Guinea pigs; Listeriosis; Placenta; Infection; Pregnancy; Cytokine; Apoptosis;

D O I：

10.1016/j.reprotox.2008.07.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stillbirths and spontaneous abortions can result when pregnant women are exposed to the food borne pathogen, Listeria monocytogenes. Fetuses and neonates account for one-third of the 2500 cases annually. The objectives were to determine the dose dependent trends of immunological and pathological effects in pregnant guinea pigs after infection with L. monocytogenes. Timed pregnant guinea pigs were treated on gestation day (gd) 35 with doses of 10(4) to 10(8) Colony forming units (CFUs) and sacrificed on gd 56. Hepatic lesions were found in dams treated with >= 10(5) CFUs. Apoptosis was detected in significantly more placentas from dams treated with >= 10(6) CFUs compared to controls. Maternal serum TNF-alpha concentrations were significantly decreased in all dose groups compared to controls. in conclusion, increases in premature delivery, maternal hepatic effects and placental apoptosis along with a decrease in TNF-alpha concentrations were associated with L. monocytogenes infection in pregnant guinea pigs. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：123 / 129

页数：7

共 31 条

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