Survivin Expression in Renal Cell Carcinoma

被引：60

作者：

Zamparese, Rosanna ^{[1
]}

Pannone, Giuseppe ^{[1
]}

Santoro, Angela ^{[1
]}

Lo Muzio, Lorenzo ^{[1
]}

Corsi, Fabrizio ^{[1
]}

Pedicillo, Maria C. ^{[1
]}

Scillitani, Ester L. ^{[1
]}

Tortorella, Simona ^{[1
]}

Staibano, Stefania ^{[2
]}

Piscuoglio, Salvatore ^{[2
]}

Lo Russo, Lucio ^{[1
]}

Bufo, Pantaleo ^{[1
]}

机构：

[1] Univ Foggia, Dept Surg Sci, Foggia, Italy

[2] Univ Naples Federico II, Dept Biomorphol & Funct Sci, Naples, Italy

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 09期

关键词：

Programmed cell death; Survivin; Renal clear cell carcinoma; Disease specific survival;

D O I：

10.1080/07357900802017553

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Deregulated expression of inhibitors of apoptosis may contribute to cancer by aberrantly extending cell viability and facilitating the insurgence of resistance to chemo- and radiotherapy. In this study, we have investigated, by immunohistochemical technique, the expression and potential prognostic significance of survivin in a series of 49 clear cell type renal cell carcinoma (ccRCC). Survivin expression was significantly associated with poorly differentiated, advanced stages and more aggressive ccRCCs (p 0.05). Patients with low survivin expression had statistically significant better survival rates than patients with high survivin expression (p 0.05). This may be relevant for follow-up protocols design and/or alternative therapeutic approaches.

引用

页码：929 / 935

页数：7

共 46 条

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