Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors

被引：50

作者：

Carroll, Shannon H. ^{[1
]}

Ravid, Katya ^{[2
,3
,4
]}

机构：

[1] Boston Univ, Sch Med, Dept Biochem, Boston, MA USA

[2] Boston Univ, Sch Med, Dept Med, Boston, MA USA

[3] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA USA

[4] Boston Univ, Sch Med, Evans Ctr Interdisciplinary Biomed Res, Boston, MA USA

来源：

EXPERT REVIEWS IN MOLECULAR MEDICINE | 2013年 / 15卷

关键词：

NECROSIS-FACTOR-ALPHA; BONE-MINERAL DENSITY; MESSENGER-RNA EXPRESSION; HORMONE-RELATED PEPTIDE; AUTOSOMAL SEX REVERSAL; PARATHYROID-HORMONE; PROTEIN-KINASE; OSTEOGENIC DIFFERENTIATION; TRANSCRIPTIONAL REGULATION; CAMPOMELIC DYSPLASIA;

D O I：

10.1017/erm.2013.2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Skeletogenesis, either during development, post-injury or for maintenance, is a carefully coordinated process reliant on the appropriate differentiation of mesenchymal stem cells. Some well described, as well as a new regulator of this process (adenosine receptors), are alike in that they signal via cyclic-AMP (cAMP). This review highlights the known contribution of cAMP signalling to mesenchymal stem cell differentiation to osteoblasts and to chondrocytes. Focus has been given to how these regulators influence the commitment of the osteochondroprogenitor to these separate lineages.

引用

页数：12

共 127 条

[1]

EXPRESSION CLONING OF A COMMON RECEPTOR FOR PARATHYROID-HORMONE AND PARATHYROID HORMONE-RELATED PEPTIDE FROM RAT OSTEOBLAST-LIKE CELLS - A SINGLE RECEPTOR STIMULATES INTRACELLULAR ACCUMULATION OF BOTH CAMP AND INOSITOL TRISPHOSPHATES AND INCREASES INTRACELLULAR FREE CALCIUM [J].

ABOUSAMRA, AB ;

JUPPNER, H ;

FORCE, T ;

FREEMAN, MW ;

KONG, XF ;

SCHIPANI, E ;

URENA, P ;

RICHARDS, J ;

BONVENTRE, JV ;

POTTS, JT ;

KRONENBERG, HM ;

SEGRE, GV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2732-2736

[2]

On the Role of Subtype Selective Adenosine Receptor Agonists During Proliferation and Osteogenic Differentiation of Human Primary Bone Marrow Stromal Cells [J].

Adelina Costa, M. ;

Barbosa, A. ;

Neto, E. ;

Sa-e-Sousa, A. ;

Freitas, R. ;

Neves, J. M. ;

Magalhaes-Cardoso, T. ;

Ferreirinha, F. ;

Correia-de-Sa, P. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2011, 226 (05) :1353-1366

[3]

The Regulation of Differentiation in Mesenchymal Stem Cells [J].

Augello, Andrea ;

De Bari, Cosimo .

HUMAN GENE THERAPY, 2010, 21 (10) :1226-1238

[4]

Signaling Pathways in Human Skeletal Dysplasias [J].

Baldridge, Dustin ;

Shchelochkov, Oleg ;

Kelley, Brian ;

Lee, Brendan .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 11, 2010, 11 :189-217

[5]

INHIBITION OF INDUCED ENDOCHONDRAL BONE-DEVELOPMENT IN CAFFEINE-TREATED RATS [J].

BARONE, LM ;

TASSINARI, MS ;

BORTELL, R ;

OWEN, TA ;

ZEROGIAN, J ;

GAGNE, K ;

STEIN, GS ;

LIAN, JB .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, 52 (02) :171-182

[6]

Adenosine Generation and Signaling during Acute Kidney Injury [J].

Bauerle, Jessica D. ;

Grenz, Almut ;

Kim, Jae-Hwan ;

Lee, H. Thomas ;

Eltzschig, Holger K. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (01) :14-20

[7]

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES - FUNCTIONAL IMPLICATIONS OF MULTIPLE ISOFORMS [J].

BEAVO, JA .

PHYSIOLOGICAL REVIEWS, 1995, 75 (04) :725-748

[8]

A twist code determines the onset of osteoblast differentiation [J].

Bialek, P ;

Kern, B ;

Yang, XL ;

Schrock, M ;

Sosic, D ;

Hong, N ;

Wu, H ;

Yu, K ;

Ornitz, DM ;

Olson, EN ;

Justice, MJ ;

Karsenty, G .

DEVELOPMENTAL CELL, 2004, 6 (03) :423-435

[9]

Blackburn M. R, 2009, HDB EXPT PHARM, V195, P215

[10]

A2B Adenosine Receptor Promotes Mesenchymal Stem Cell Differentiation to Osteoblasts and Bone Formation in Vivo [J].

Carroll, Shannon H. ;

Wigner, Nathan A. ;

Kulkarni, Nitin ;

Johnston-Cox, Hillary ;

Gerstenfeld, Louis C. ;

Ravid, Katya .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (19) :15718-15727

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