T-γ large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, Sjogrens Syndrome and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia

被引：33

作者：

Ergas, D ^{[1
]}

Tsimanis, A ^{[1
]}

Shtalrid, M ^{[1
]}

Duskin, C ^{[1
]}

Berrebi, A ^{[1
]}

机构：

[1] Hematol Inst, Kaplan Med Ctr, Rehovot, Israel

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2002年 / 69卷 / 02期

关键词：

T-gamma LGL leukemia; Sjogren's syndrome; pure red cell aplasia;

D O I：

10.1002/ajh.10024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present a female patient with T-gamma LGL leukemia, who was followed for the last 20 years. Over these years she developed several autoimmune disorders, including Sjogren's syndrome, Hashimoto's thyroiditis, premature ovarian failure (compatible with type II autoimmune polyglandular syndrome), amegakaryocytic thrombocytopenic purpura, and finally pure red cell aplasia. PCR analysis confirmed rearrangement for TCR gamma. This case emphasizes the complex association of LGL leukemia with autoimmune disorders. (C) 2002 Wiley-Liss, Inc.

引用

页码：132 / 134

页数：3

共 10 条

[1]

[Anonymous], HEMATOL J S

[2] Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure [J].