The biology of influenza viruses

被引：768

作者：

Bouvier, Nicole M. ^{[1
,2
]}

Palese, Peter ^{[1
,2
]}

机构：

[1] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Med, New York, NY USA

来源：

VACCINE | 2008年 / 26卷

关键词：

Influenza virus; RNA viruses; Antigenic shift; Antigenic drift;

D O I：

10.1016/j.vaccine.2008.07.039

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure of the influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in Viruses able to evade the long-term adaptive immune responses in many hosts. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：D49 / D53

页数：5

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