Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis

被引：53

作者：

Grouard, G

Clark, EA

机构：

[1] UNIV WASHINGTON,MED CTR,REG PRIMATE RES CTR,SEATTLE,WA 98195

[2] UNIV WASHINGTON,MED CTR,DEPT MICROBIOL,SEATTLE,WA 98195

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(97)80111-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4(+) T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus, but not actively infectious virus, yet these cells are a key regulated reservoir of virions.

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页码：563 / 567

页数：5

相关论文

共 41 条

[1]

BANCHEREAU J, 1995, DENDRITIC CELLS FUND

[2] The interaction of macrophage and non-macrophage tropic isolates of HIV-1 with thymic and tonsillar dendritic cells in vitro [J].

Cameron, PU ;

Lowe, MG ;

Sotzik, F ;

Coughlan, AF ;

Crowe, SM ;

Shortman, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1851-1856

[3] DENDRITIC CELLS EXPOSED TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TRANSMIT A VIGOROUS CYTOPATHIC INFECTION TO CD4+ T-CELLS [J].

CAMERON, PU ;

FREUDENTHAL, PS ;

BARKER, JM ;

GEZELTER, S ;

INABA, K ;

STEINMAN, RM .

SCIENCE, 1992, 257 (5068) :383-386

[4]

Canque B, 1996, BLOOD, V88, P4215

[5]

CAUX C, 1996, BLOOD CELL BIOCH, P263

[6] Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation [J].

Cella, M ;

Scheidegger, D ;

PalmerLehmann, K ;

Lane, P ;

Lanzavecchia, A ;

Alber, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :747-752

[7] In vitro HIV1 infection of CD34(+) progenitor-derived dendritic Langerhans cells at different stages of their differentiation in the presence of GM-CSF TNF alpha [J].

Charbonnier, AS ;

Verrier, B ;

Jacquet, C ;

Massacrier, C ;

Fiers, MM ;

Mallet, F ;

DezutterDambuyant, C ;

Schmitt, D .

RESEARCH IN VIROLOGY, 1996, 147 (2-3) :89-95

[8] Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge [J].

Chvatchko, Y ;

KoscoVilbois, MH ;

Herren, S ;

Lefort, J ;

Bonnefoy, JY .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (06) :2353-2360

[9] HIV: Dendritic cells as embers for the infectious fire [J].

Clark, EA .

CURRENT BIOLOGY, 1996, 6 (06) :655-657

[10]

Clark EA, 1995, ADV EXP MED BIOL, V378, P285

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