Oxcarbazepine: Efficacy, safety, and tolerability in the treatment of mania

被引：4

作者：

Lande, RG

机构：

[1] Silver Spring, MD 20906

来源：

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE | 2004年 / 8卷 / 01期

关键词：

treatment; oxcarbazepine; mania;

D O I：

10.1080/13651500310003336

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A twelve-week study examined the efficacy, safety, and tolerability of oxcarbazepine in the treatment of mania. Twenty male subjects, all of whom were stable on valproic acid, qualified for the study. The conversion from valproic acid to oxcarbazepine was completed over a three-week period. Scores from the BPRS, CGI and SATEE-GI were collected and analyzed. The results of the study supported the efficacy, safety, and tolerability of oxcarbazepine for the treatment of mania. Another potential advantage of oxcarbazepine is a metabolic pathway that may reduce drug interactions.

引用

页码：37 / 40

页数：4

共 20 条

[1] Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024 [J].

Ambrósio, AF ;

Soares-da-Silva, P ;

Carvalho, CM ;

Carvalho, AP .

NEUROCHEMICAL RESEARCH, 2002, 27 (1-2) :121-130

[2] THE INFLUENCE OF FOOD ON THE DISPOSITION OF THE ANTIEPILEPTIC OXCARBAZEPINE AND ITS MAJOR METABOLITES IN HEALTHY-VOLUNTEERS [J].

DEGEN, PH ;

FLESCH, G ;

CARDOT, JM ;

CZENDLIK, C ;

DIETERLE, W .

BIOPHARMACEUTICS & DRUG DISPOSITION, 1994, 15 (06) :519-526

[3]

Dunn RT, 1998, CLIN NEUROPHARMACOL, V21, P215

[4]

EMRICH HM, 1990, INT CLIN PSYCHOPHARM, V5, P83

[5] Plasma level monitoring of oxcarbazepine in epileptic patients [J].

González-Esquivel, DF ;

Ortega-Gavilán, M ;

Alcántara-López, G ;

Jung-Cook, H .

ARCHIVES OF MEDICAL RESEARCH, 2000, 31 (02) :202-205

[6]

GREIL W, 1985, PSYCHIAT STATE ART, V3, P491

[7]

Guy W., 1976, ECDEU ASSESSMENT MAN, P217, DOI DOI 10.1016/J.BIOPHA.2016.11.034

[8] ABSENCE OF INTERACTION BETWEEN OXCARBAZEPINE AND ERYTHROMYCIN [J].

KERANEN, T ;

JOLKKONEN, J ;

JENSEN, PK ;

MENGE, GP ;

ANDERSSON, P .

ACTA NEUROLOGICA SCANDINAVICA, 1992, 86 (02) :120-123

[9]

KERANEN T, 1992, ACTA NEUROL SCAND, V85, P239

[10] Carbamazepine and oxcarbazepine decrease phenytoin metabolism through inhibition of CYP2C19 [J].

Lakehal, F ;

Wurden, CJ ;

Kalhorn, TF ;

Levy, RH .

EPILEPSY RESEARCH, 2002, 52 (02) :79-83

← 1 2 →