Cloning of the cDNA encoding the mouse ATBF1 transcription factor

被引：36

作者：

Ido, A

Miura, Y

Watanabe, M

Sakai, M

Inoue, Y

Miki, T

Hashimoto, T

Morinaga, T

Nishi, S

Tamaoki, T

机构：

[1] UNIV CALGARY,DEPT MED BIOCHEM,CALGARY,AB T2N 4N1,CANADA

[2] HOKKAIDO UNIV,SCH MED,DEPT ANAT,SAPPORO,HOKKAIDO 060,JAPAN

[3] HOKKAIDO UNIV,DEPT BIOCHEM,SAPPORO,HOKKAIDO 060,JAPAN

[4] NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892

[5] HYOGO MED UNIV,DEPT GENET,NISHINOMIYA,HYOGO 663,JAPAN

[6] SNOW BRAND MILK PROD CO LTD,LIFE SCI RES INST,ISHIBASHI,TOCHIGI 32905,JAPAN

来源：

GENE | 1996年 / 168卷 / 02期

关键词：

homeodomain; zinc finger; brain; RNase protection assay;

D O I：

10.1016/0378-1119(95)00740-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have isolated a mouse ATBF1 cDNA which is 12-kb long and capable of encoding a 406-kDa protein containing four homeodomains and 23 zinc-finger motifs. Mouse ATBF1 is 94% homologous to the human ATBF1-A transcription factor. Northern blot and RNase protection analysis showed that levels of ATBF1 transcripts were low in adult mouse tissues, but high in developing brain, consistent with a role for ATBF1 in neuronal differentiation.

引用

页码：227 / 231

页数：5

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