Restriction of nutrient intake results in the increase of a specific Manduca sexta allatotropin (Manse-AT) mRNA in the larval nerve cord

被引：18

作者：

Lee, KY

Horodyski, FM

机构：

[1] Ohio Univ, Coll Osteopath Med, Athens, OH 45701 USA

[2] Ohio Univ, Dept Biomed Sci, Athens, OH 45701 USA

[3] Ohio Univ, Mol & Cellular Biol Program, Athens, OH 45701 USA

来源：

PEPTIDES | 2002年 / 23卷 / 04期

基金：

美国国家科学基金会;

关键词：

juvenile hormone; alternative splicing; neuropeptides; starvation; tebufenozide; parasitism;

D O I：

10.1016/S0196-9781(01)00659-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Manduca allatotropin (Manse-AT) gene is expressed as three mRNAs that differ from each other by alternative splicing. The level of one of these mRNAs (RNA-3) is specifically increased in the nerve cord of last instar larvae that were starved, parasitized, or fed the ecdysteroid agonist RH-5992. Each of these treatments results in reduction of feeding and increased levels of juvenile hormone (JH). The normal decline in JH biosynthesis by the corpora allata does not occur in starved or RH-5992-fed larvae. The increase in RNA-3 levels has the capacity to increase the production of Manse-AT and two related peptides that may be part of the complex response of larvae to nutrient deprivation. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：653 / 661

页数：9

共 60 条

[1] Juvenile hormone biosynthesis by corpora allata of larval tomato moth, Lacanobia oleracea, and regulation by Manduca sexta allatostatin and allatotropin [J].