T cell status influences colon tumor occurrence in Min mice fed short chain fructo-oligosaccharides as a diet supplement

被引:40
作者
Pierre, F
Perrin, P
Bassonga, E
Bornet, F
Meflah, K
Menanteau, J
机构
[1] Inst Natl Sante & Rech Med U419, Human Nutr Res Ctr, Inst Biol, F-44035 Nantes 01, France
[2] Vilvoorde Res & Dev Ctr, Nutr & Hlth Serv, B-1800 Vilvoorde, Belgium
关键词
D O I
10.1093/carcin/20.10.1953
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We have previously shown that addition of short chain fructo-oligosaccharides (indigestible carbohydrates) to food prevented colon tumors in C57BL/6-Apc(Min/+) mice, a model for human colon cancer. As gut-associated lymphoid tissue was concomitantly developed, we suggested that the immune response generated by this food may interfere with carcinogenesis due to involvement of mucosal cells in the regulation of tissue homeostasis. In the present experiment, we tested whether T cell status may influence colon tumor formation in Min mice fed a food supplement of short chain fructo-oligosaccharides. Min mice depleted of CD4(+) and CD8(+) lymphocytes developed twice as many tumors as immunocompetent mice (0.8 as compared with 0.4, the mean number in 7-week-old Min mice when food supplementation began; P = 0.02), It is concluded that food supplementation with a substrate (a known prebiotic) fermented in the colon may stimulate a mechanism of immunosurveillance that would otherwise remain inefficient.
引用
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页码:1953 / 1956
页数:4
相关论文
共 26 条
[1]   IMMUNOLOGICAL SURVEILLANCE AGAINST CHEMICALLY-INDUCED PRIMARY COLON CARCINOMA IN RATS [J].
BANSAL, SC ;
MARK, R ;
BANSAL, BR ;
RHOADS, JE .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1978, 60 (03) :667-675
[2]  
CAMERINI V, 1993, J IMMUNOL, V151, P1761
[3]  
Dove WF, 1997, CANCER RES, V57, P812
[4]  
Dudley ME, 1996, INT J CANCER, V65, P249, DOI 10.1002/(SICI)1097-0215(19960117)65:2<249::AID-IJC20>3.0.CO
[5]  
2-7
[6]   Dietary fiber and the risk of colorectal cancer and adenoma in women [J].
Fuchs, CS ;
Giovannucci, EL ;
Colditz, GA ;
Hunter, DJ ;
Stampfer, MJ ;
Rosner, B ;
Speizer, FE ;
Willett, WC .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (03) :169-176
[7]   Suppression of intestinal polyp development by low-fat and high-fiber diet in Apc(Delta 716) knockout mice [J].
Hioki, K ;
Shivapurkar, N ;
Oshima, H ;
Alabaster, O ;
Oshima, M ;
Taketo, MM .
CARCINOGENESIS, 1997, 18 (10) :1863-1865
[8]   Dietary fat and fiber differentially alter intracellular second messengers during tumor development in rat colon [J].
Jiang, YH ;
Lupton, JR ;
Chang, WCL ;
Jolly, CA ;
Aukema, HM ;
Chapkin, RS .
CARCINOGENESIS, 1996, 17 (06) :1227-1233
[9]   Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice [J].
Kaplan, DH ;
Shankaran, V ;
Dighe, AS ;
Stockert, E ;
Aguet, M ;
Old, LJ ;
Schreiber, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7556-7561
[10]   The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand [J].
OConnell, J ;
OSullivan, GC ;
Collins, JK ;
Shanahan, F .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :1075-1082