Polysaccharicles from Hibiscus sabdariffa flowers stimulate proliferation and differentiation of human keratinocytes

被引：24

作者：

Brunold, C

Deters, A

Knoepfel-Sidler, F

Hafner, J

Müller, B

Hensel, A ^{[1
]}

机构：

[1] Univ Appl Sci Wadenswil, CH-8820 Wadenswil, Switzerland

[2] Univ Appl Sci Wadenswil, Zurich, Switzerland

来源：

PLANTA MEDICA | 2004年 / 70卷 / 04期

关键词：

D O I：

10.1055/s-2004-818952

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Raw polysaccharides, previously described in detail, were isolated from the flowers of Hibiscus sabdariffa L. and fractionated by ion exchange chromatography into one neutral and three acidic subfractions. Raw polysaccharides and all acidic subfractions caused a strong induction of proliferation of human keratinocytes (HaCaT) of up to 40%, while the neutral polymers were ineffective. While mitochondrial activity was not influenced, raw polysaccharides induced early differentiation of primary natural human keratinocytes, as determined by involucrin formation.

引用

页码：370 / 373

页数：4

共 13 条

[1]

AMADOR E, 1963, CLIN CHEM, V9, P391

[2] Simarouba amara extract increases human skin keratinocyte differentiation [J].