White opaque substance within superficial elevated gastric neoplasia as visualized by magnification endoscopy with narrow-band imaging: a new optical sign for differentiating between adenoma and carcinoma

被引：134

作者：

Yao, Kenshi ^{[1
]}

Iwashita, Akinori ^{[2
]}

Tanabe, Hiroshi ^{[1
]}

Nishimata, Nobuaki ^{[1
]}

Nagahama, Takashi ^{[1
]}

Maki, Shinichiro ^{[1
]}

Takaki, Yasuhiro ^{[1
]}

Hirai, Fumihito ^{[1
]}

Hisabe, Takashi ^{[1
]}

Nishimura, Taku ^{[1
]}

Matsui, Toshiyuki ^{[1
]}

机构：

[1] Fukuoka Univ, Chikushi Hosp, Dept Gastroenterol, Fukuoka 8188502, Japan

[2] Fukuoka Univ, Chikushi Hosp, Dept Pathol, Fukuoka 8188502, Japan

来源：

GASTROINTESTINAL ENDOSCOPY | 2008年 / 68卷 / 03期

关键词：

D O I：

10.1016/j.gie.2008.04.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: The microvascular pattern (MVP) as visualized by magnification endoscopy (ME) is a reliable marker for differentiating between benign and malignant gastric flat lesions. However, in cases of gastric neoplasia of 0-IIa type, it is sometimes impossible to visualize the MVP because a white opaque substance (WOS) obscures the subepithelial MVP. Objective: To investigate whether the morphology of the WOS could be useful optical sign for discriminating between adenoma and carcinoma. Setting: Single tertiary referral center. Materials: Forty-six gastric neoplasias of only 0-IIa type (18 adenomas and 28 early carcinomas) were evaluated. Intervention: The prevalence and the morphology of the WOS as visualized by ME with narrow-band imaging (NBI) according to histologic type (adenoma vs carcinoma). Main Outcome Measurements: The WOS is more frequently present in adenomas than in carcinomas. With regard to the morphology of the WOS, 100% of the examples of WOS within adenomas demonstrated a regular distribution; in contrast, 83% of the examples of WOS within carcinomas showed an irregular distribution. Results: In cases in which a neoplasia of 0-IIA type showed either WOS with a regular distribution or a regular MVP, the sensitivity and specificity for discriminating adenoma from carcinoma were 94% and 96%, respectively. Limitations: The number of cases was limited. The WOS has not yet been characterized by chemical analysis. Conclusion: In cases in which the WOS is observed, rather than assessing the MVP, morphologic analysis of the WOS could be an alternative new optical sign for discriminating adenoma from carcinoma when using ME with NBI.

引用

页码：574 / 580

页数：7

共 26 条

[1] Novel endoscopic observation in Barrett's oesophagus using high resolution magnification endoscopy and narrow band imaging [J].

Anagnostopoulos, G. K. ;

Yao, K. ;

Kaye, P. ;

Hawkey, C. J. ;

Ragunath, K. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2007, 26 (03) :501-507

[2]

[Anonymous], 2003, GASTROINTEST ENDOSC, V58, pS3

[3]

[Anonymous], 2000, DIG ENDOSC

[4]

Arima M, 2005, Esophagus, V2, P191, DOI [10.1007/s10388-005-0060-6, DOI 10.1007/S10388-005-0060-6]

[5]

Day DW, 2003, MORSON DAWSONS GASTR, P162

[6] CLINICAL-SIGNIFICANCE OF GASTRIC DYSPLASIA - A MULTICENTER FOLLOW-UP-STUDY [J].

FERTITTA, AM ;

COMIN, U ;

TERRUZZI, V ;

MINOLI, G ;

ZAMBELLI, A ;

CANNATELLI, G ;

BODINI, P ;

BERTOLI, G ;

NEGRI, R ;

BRUNATI, S ;

FIOCCA, R ;

TURPINI, F ;

PRADA, A ;

CERETTI, E ;

GULLOTTA, R ;

CORNAGGIA, M .

ENDOSCOPY, 1993, 25 (04) :265-268

[7] Endoscopic observation of tissue by narrowband illumination [J].

Gono, K ;

Yamazaki, K ;

Doguchi, N ;

Nonami, T ;

Obi, T ;

Yamaguchi, M ;

Ohyama, N ;

Machida, H ;

Sano, Y ;

Yoshida, S ;

Hamamoto, Y ;

Endo, T .

OPTICAL REVIEW, 2003, 10 (04) :211-215

[8]

GONO K, 2007, COMPREHENSIVE ATLAS, P9

[9] Incidence of lymph node metastasis from early gastric cancer: Estimation with a large number of cases at two large centers [J].

Gotoda T. ;

Yanagisawa A. ;

Sasako M. ;

Ono H. ;

Nakanishi Y. ;

Shimoda T. ;

Kato Y. .

Gastric Cancer, 2000, 3 (4) :219-225

[10]

KAMIYA T, 1982, CANCER, V50, P2496, DOI 10.1002/1097-0142(19821201)50:11<2496::AID-CNCR2820501140>3.0.CO

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