Artificial organelle: ATP synthesis from cellular mimetic polymersomes

被引：286

作者：

Choi, HJ ^{[1
]}

Montemagno, CD ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

来源：

NANO LETTERS | 2005年 / 5卷 / 12期

关键词：

D O I：

10.1021/nl051896e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A complex cellular process was reconstructed using a multiprotein polymersome system. ATP has been produced by coupled reactions between bacteriorhodopsin, a light-driven transmembrane proton pump, and F(0)F(1)-ATP synthase motor protein, reconstituted in polymersomes. This indicates that ATP synthase maintained its ATP synthesis and therefore its motor activity in the artificial membranes. This hybrid proteopolymersome will have wide application in a number of fields ranging from the in vitro investigation of cellular metabolism to the synthesis of functional "smart" materials.

引用

页码：2538 / 2542

页数：5

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