Biology and therapy of fibromyalgia - Evidence-based biomarkers for fibromyalgia syndrome

被引：95

作者：

Dadabhoy, Dina ^{[2
]}

Crofford, Leslie J. ^{[3
]}

Spaeth, Michael ^{[4
]}

Russell, I. Jon ^{[5
]}

Clauw, Daniel J. ^{[1
,6
]}

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48105 USA

[2] NW Rheumatol Specialists, Elk Grove Village, IL 60007 USA

[3] Univ Kentucky, Dept Internal Med, Lexington, KY 40536 USA

[4] Ctr Clin Rheumatol Res, D-82166 Graefelfing Munich, Germany

[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA

[6] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48105 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2008年 / 10卷 / 04期

关键词：

D O I：

10.1186/ar2443

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Researchers studying fibromyalgia strive to identify objective, measurable biomarkers that may identify susceptible individuals, may facilitate diagnosis, or that parallel activity of the disease. Candidate objective measures range from sophisticated functional neuroimaging to office-ready measures of the pressure pain threshold. A systematic literature review was completed to assess highly investigated, objective measures used in fibromyalgia studies. To date, only experimental pain testing has been shown to coincide with improvements in clinical status in a longitudinal study. Concerted efforts to systematically evaluate additional objective measures in research trials will be vital for ongoing progress in outcome research and translation into clinical practice.

引用

页数：18

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