The absolute stereochemistry of kahalalide F

被引：28

作者：

Goetz, G ^{[1
]}

Yoshida, WY ^{[1
]}

Scheuer, PJ ^{[1
]}

机构：

[1] Univ Hawaii, Dept Chem, Honolulu, HI 96822 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 25期

关键词：

antitumor compounds; depsipeptides; marine metabolites; stereochemistry;

D O I：

10.1016/S0040-4020(99)00410-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kahalalide F (1) is a depsipeptide of 14 residues, five of which form a 19-membered ring. It was isolated from a marine mollusk, Elysia rufescens, and is currently in preclinical trials against lung and colon cancers. It was known from conventional amino acid analysis that five valine and two threonine residues represented D- and L- enantiomers, but their position in the molecule was not known. After extensive hydrolytic trials, a combination of acid hydrolysis and hydrazinolysis succeeded in definitive stereochemical assignment. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7739 / 7746

页数：8

共 6 条

[1] Two acyclic kahalalides from the sacoglossan mollusk Elysia rufescens [J].