Chiral pyrrolidinium salts as organocatalysts in the stereoselective 1,4-conjugate addition of N-methylpyrrole to cyclopent-1-ene carbaldehyde

被引：17

作者：

Breistein, P

Karlsson, S

Hedenström, E

机构：

[1] Mid Sweden Univ, Dept Nat Sci, SE-85170 Sundsvall, Sweden

[2] AstraZeneca R&D, SE-43183 Molndal, Sweden

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 01期

关键词：

D O I：

10.1016/j.tetasy.2005.11.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A variety of enantiopure proline derived pyrrolidinium (HX)(n) salts have been found to catalyse the 1,4-conjugate addition of AT-methylpyrrole to cyclopent-1-ene carbaldehyde with, in some cases, high diastereo- and enantioselectivity. Parameters such as water activity, choice of acidic cocatalyst (HX)(n) and also the amount of cocatalyst used turned out to be crucial for the diastereo- and enantioselectivity of the reaction. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：107 / 111

页数：5

共 12 条

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