Interleukin-19 in Breast Cancer

被引：20

作者：

Chen, Ying-Yin ^{[1
,2
,3
]}

Li, Chien-Feng ^{[4
]}

Yeh, Ching-Hua ^{[5
]}

Chang, Ming-Shi ^{[6
]}

Hsing, Chung-Hsi ^{[1
,2
,7
]}

机构：

[1] Chi Mei Med Ctr, Dept Med Res, Tainan 710, Taiwan

[2] Chi Mei Med Ctr, Dept Anesthesiol, Tainan 710, Taiwan

[3] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan

[4] Chi Mei Med Ctr, Dept Pathol, Tainan 710, Taiwan

[5] Chang Jung Christian Univ, Coll Hlth Sci, Inst Med Sci, Tainan 711, Taiwan

[6] Natl Cheng Kung Univ, Coll Med, Inst Biochem & Mol Biol, Tainan 701, Taiwan

[7] Taipei Med Univ, Coll Med, Dept Anesthesiol, Taipei 110, Taiwan

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2013年

关键词：

POTENTIAL ROLE; TH2; CYTOKINES; GROWTH-FACTOR; CUTTING EDGE; IL-10; FAMILY; IMMUNE CELLS; RAT BREAST; TGF-BETA; INFLAMMATION; RECEPTOR;

D O I：

10.1155/2013/294320

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Inflammatory cytokines within the tumor microenvironment are linked to progression in breast cancer. Interleukin-(IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis. IL-19 is expressed in several types of tumor cells, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung and invasive duct carcinoma of the breast. In breast cancer, IL-19 expression is correlated with increased mitotic figures, advanced tumor stage, higher metastasis, and poor survival. The mechanisms of IL-19 in breast cancer have recently been explored both in vitro and in vivo. IL-19 has an autocrine effect in breast cancer cells. It directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression, which suggests that IL-19 is a prognostic marker in breast cancer and that antagonizing IL-19 may have therapeutic potential.

引用

页数：9

共 65 条

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Interleukin-19 Protects Mice from Innate-mediated Colonic Inflammation [J].