Synergistic antitumor effects of immune cell-viral biotherapy

被引：249

作者：

Thorne, SH

Negrin, RS

Contag, CH ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Microbiol, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Dept Immunol, Stanford, CA 94305 USA

[5] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[6] Stanford Univ, Sch Med, Div Bone Marrow Transplantat, Stanford, CA 94305 USA

来源：

SCIENCE | 2006年 / 311卷 / 5768期

关键词：

D O I：

10.1126/science.1121411

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Targeted biological therapies hold tremendous potential for treatment of cancer, yet their use has been limited by constraints on delivery and effective tumor targeting. We combined an immune effector cell population [cytokine-induced killer (CIK) cells] with an oncolytic viral therapy to achieve directed delivery to, and regression of, tumors in both immunodeficient and immunocompetent mouse models. Preinfection of CIK cells with modified vaccinia virus resulted in a prolonged eclipse phase with the virus remaining hidden until interaction with the tumor. Whole-body imaging revealed that the cells retained their ability to traffic to and to infiltrate the tumor effectively before releasing the virus. These results illustrate the potential of combining biotherapeutics for synergistic effects that more. effectively treat cancer.

引用

页码：1780 / 1784

页数：5

共 25 条

[1]

The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication [J].