Regioselective synthesis and side-chain metallation and elaboration of 3-aryl-5-alkylisoxazoles

被引：24

作者：

Di Nunno, L ^{[1
]}

Scilimati, A ^{[1
]}

Vitale, P ^{[1
]}

机构：

[1] Univ Bari, Dipartimento Farmaco Chim, I-70125 Bari, Italy

来源：

TETRAHEDRON | 2002年 / 58卷 / 13期

关键词：

isoxazolines; isoxazoles; synthesis; metallation;

D O I：

10.1016/S0040-4020(02)00125-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A number of 3-aryl-5-alkylisoxazoles have been synthesized in high yields by reacting arylnitrile oxides with free enolate ions regioselectively obtained by metallation of various alkyl methyl ketones with LDA in THF at -78degreesC followed by dehydration. Investigations concerning regioselective side-chain metallation and elaboration of one of them (3-phenyl-5-ethylisoxazole) have also been carried out. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2659 / 2665

页数：7

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