Human BSE

被引：76

作者：

Almond, J ^{[1
]}

Pattison, J ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,SCH MED,LONDON WC1E 6BT,ENGLAND

来源：

NATURE | 1997年 / 389卷 / 6650期

关键词：

D O I：

10.1038/38876

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two sets of studies, using different approaches, provide convincing evidence that the new variant of Creutzfeldt-Jakob disease (vCJD) is caused by the agent that is responsible for BSE in cattle. Like Creutzfeldt-Jakob disease itself, vCJD is a human neurological disorder that leads to brain damage and death; but it is clinically and pathologically distinct, not least in afflicting younger people. The new studies cannot however tell us anything about a crucial issue — the future number of cases of this variant disease.

引用

页码：437 / 438

页数：2

共 12 条

[1] TRANSMISSION OF BOVINE SPONGIFORM ENCEPHALOPATHY AND SCRAPIE TO MICE - STRAIN VARIATION AND THE SPECIES BARRIER
BRUCE, M
CHREE, A
MCCONNELL, I
FOSTER, J
PEARSON, G
FRASER, H
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1994, 343 (1306) : 405 - 411
[2] SCRAPIE STRAIN VARIATION AND MUTATION
BRUCE, ME
[J]. BRITISH MEDICAL BULLETIN, 1993, 49 (04) : 822 - 838
[3] Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent
Bruce, ME
Will, RG
Ironside, JW
McConnell, I
Drummond, D
Suttie, A
McCardle, L
Chree, A
Hope, J
Birkett, C
Cousens, S
Fraser, H
Bostock, CJ
[J]. NATURE, 1997, 389 (6650) : 498 - 501
[4] THE DISEASE CHARACTERISTICS OF DIFFERENT STRAINS OF SCRAPIE IN SINC CONGENIC MOUSE LINES - IMPLICATIONS FOR THE NATURE OF THE AGENT AND HOST CONTROL OF PATHOGENESIS
BRUCE, ME
MCCONNELL, I
FRASER, H
DICKINSON, AG
[J]. JOURNAL OF GENERAL VIROLOGY, 1991, 72 : 595 - 603
[5] Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
Collinge, J
Sidle, KCL
Meads, J
Ironside, J
Hill, AF
[J]. NATURE, 1996, 383 (6602) : 685 - 690
[6] Predicting the CJD epidemic in humans
Cousens, SN
Vynnycky, E
Zeidler, M
Will, RG
Smith, PG
[J]. NATURE, 1997, 385 (6613) : 197 - 198
[7] Type of prion protein in UK farmers with Creutzfeldt-Jakob disease
Hill, AF
Will, RG
Ironside, J
Collinge, J
[J]. LANCET, 1997, 350 (9072) : 188 - 188
[8] The same prion strain causes vCJD and BSE
Hill, AF
Desbruslais, M
Joiner, S
Sidle, KCL
Gowland, I
Collinge, J
Doey, LJ
Lantos, P
[J]. NATURE, 1997, 389 (6650) : 448 - 450
[9] BSE transmission to macaques
Lasmezas, CI
Deslys, JP
Demaimay, R
Adjou, KT
Lamoury, F
Dormont, D
Robain, O
Ironside, J
Hauw, JJ
[J]. NATURE, 1996, 381 (6585) : 743 - 744
[10] HOMOZYGOUS PRION PROTEIN GENOTYPE PREDISPOSES TO SPORADIC CREUTZFELDT-JAKOB DISEASE
PALMER, MS
DRYDEN, AJ
HUGHES, JT
COLLINGE, J
[J]. NATURE, 1991, 352 (6333) : 340 - 342

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