New insights into myosin evolution and classification

被引:351
作者
Foth, BJ [1 ]
Goedecke, MC [1 ]
Soldati, D [1 ]
机构
[1] Univ Geneva, Ctr Med Univ, Dept Microiol & Mol Med, CH-1211 Geneva, Switzerland
基金
英国惠康基金;
关键词
Apicomplexa; Chromalveolata;
D O I
10.1073/pnas.0506307103
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Myosins are eukaryotic actin-dependent molecular motors important for a broad range of functions like muscle contraction, vision, hearing, cell motility, and host cell invasion of apicomplexan parasites. Myosin heavy chains consist of distinct head, neck, and tail domains and have previously been categorized into 18 different classes based on phylogenetic analysis of their conserved heads. Here we describe a comprehensive phylogenetic examination of many previously unclassified myosins, with particular emphasis on sequences from apicomplexan and other chromalveolate protists including the model organism Toxoplasma, the malaria parasite Plasmodium, and the ciliate Tetrahymena. Using different phylogenetic inference methods and taking protein domain architectures, specific amino acid polymorphisms, and organismal distribution into account, we demonstrate a hitherto unrecognized common origin for ciliate and apicomplexan class XIV myosins. Our data also suggest common origins for some apicomplexan myosins and class VI, for classes II and XVIII, for classes XII and XV, and for some microsporidian myosins and class V, thereby reconciling evolutionary history and myosin structure in several cases and corroborating the common coevolution of myosin head, neck, and tail domains. Six novel myosin classes are established to accommodate sequences from chordate metazoans (class XIX), insects (class XX), kinetoplastids (class XXI), and apicomplexans and diatom algae (classes XXII, XXIII, and XXIV). These myosin (sub)classes include sequences with protein domains (FYVE, WW, UBA, ATS1-like, and WD40) previously unknown to be associated with myosin motors. Regarding the apicomplexan "myosome," we significantly update class XIV classification, propose a systematic naming convention, and discuss possible functions in these parasites.
引用
收藏
页码:3681 / 3686
页数:6
相关论文
共 50 条
[1]   The new higher level classification of eukaryotes with emphasis on the taxonomy of protists [J].
Adl, SM ;
Simpson, AGB ;
Farmer, MA ;
Andersen, RA ;
Anderson, OR ;
Barta, JR ;
Bowser, SS ;
Brugerolle, G ;
Fensome, RA ;
Fredericq, S ;
James, TY ;
Karpov, S ;
Kugrens, P ;
Krug, J ;
Lane, CE ;
Lewis, LA ;
Lodge, J ;
Lynn, DH ;
Mann, DG ;
McCourt, RM ;
Mendoza, L ;
Moestrup, O ;
Mozley-Standridge, SE ;
Nerad, TA ;
Shearer, CA ;
Smirnov, AV ;
Spiegel, FW ;
Taylor, MFJR .
JOURNAL OF EUKARYOTIC MICROBIOLOGY, 2005, 52 (05) :399-451
[2]   Plasmodium biology:: Genomic gleanings [J].
Aravind, L ;
Iyer, LM ;
Wellems, TE ;
Miller, LH .
CELL, 2003, 115 (07) :771-785
[3]   Analysis of the compositional biases in Plasmodium falciparum genome and proteome using Arabidopsis thaliana as a reference [J].
Bastien, O ;
Lespinats, S ;
Roy, S ;
Métayer, K ;
Fertil, B ;
Codani, JJ ;
Maréchal, E .
GENE, 2004, 336 (02) :163-173
[4]   A millennial myosin census [J].
Berg, JS ;
Powell, BC ;
Cheney, RE .
MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (04) :780-794
[5]   Myosin VI: Cellular functions and motor properties [J].
Buss, F ;
Spudich, G ;
Kendrick-Jones, J .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2004, 20 :649-676
[6]   Principles of protein and lipid targeting in secondary symbiogenesis: Euglenoid, dinoflagellate, and sporozoan plastid origins and the eukaryote family tree [J].
Cavalier-Smith, T .
JOURNAL OF EUKARYOTIC MICROBIOLOGY, 1999, 46 (04) :347-366
[7]   KINGDOM PROTOZOA AND ITS 18 PHYLA [J].
CAVALIERSMITH, T .
MICROBIOLOGICAL REVIEWS, 1993, 57 (04) :953-994
[8]   Plasmodium falciparum myosins:: Transcription and translation during asexual parasite development [J].
Chaparro-Olaya, J ;
Margos, A ;
Coles, DJ ;
Dluzewski, AR ;
Mitchell, GH ;
Wasserman, MM ;
Pinder, JC .
CELL MOTILITY AND THE CYTOSKELETON, 2005, 60 (04) :200-213
[9]   Myosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia [J].
Chen, ZY ;
Hasson, T ;
Zhang, DS ;
Schwender, BJ ;
Derfler, BH ;
Mooseker, MS ;
Corey, DP .
GENOMICS, 2001, 72 (03) :285-296
[10]   Multiple sequence alignment with the Clustal series of programs [J].
Chenna, R ;
Sugawara, H ;
Koike, T ;
Lopez, R ;
Gibson, TJ ;
Higgins, DG ;
Thompson, JD .
NUCLEIC ACIDS RESEARCH, 2003, 31 (13) :3497-3500