Missing pieces in the NF-κB puzzle

被引：3226

作者：

Ghosh, S

Karin, M

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biophys & Biochem,Sect Immunobiol, New Haven, CT 06520 USA

[2] Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

来源：

CELL | 2002年 / 109卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(02)00703-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.

引用

页码：S81 / S96

页数：16

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