Can targeting ANGPTL proteins improve glucose tolerance?

被引：25

作者：

Davies, Brandon S. J. ^{[1
,2
]}

机构：

[1] Univ Iowa, Carver Coll Med, Dept Biochem, Fraternal Order Eagles Diabet Res Ctr, 169 Newton Rd, Iowa City, IA 52242 USA

[2] Univ Iowa, Carver Coll Med, Obes Res & Educ Initiat, 169 Newton Rd, Iowa City, IA 52242 USA

来源：

DIABETOLOGIA | 2018年 / 61卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Diabetes; Gutmicrobiota; Insulin sensitivity; Lipolysis; Lipoprotein lipase; Lipoproteins; ANGIOPOIETIN-LIKE PROTEIN-4; CORONARY-ARTERY-DISEASE; LIPOPROTEIN-LIPASE; TRIGLYCERIDE-METABOLISM; ADIPOSE-TISSUE; MICE; HYPERLIPIDEMIA; BETATROPHIN; HOMEOSTASIS; DEFICIENCY;

D O I：

10.1007/s00125-018-4604-4

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Three members of the angiopoietin-like (ANGPTL) family of proteins, ANGPTL3, ANGPTL4 and ANGPTL8, are known regulators of plasma triacylglycerol levels. Recently, these three proteins have garnered considerable interest as potential targets for therapeutically reducing plasma triacylglycerol levels and improving cardiovascular outcomes. In this issue of Diabetologia, Janssen et al (https://doi.org/10.1007/s00125-018-4583-5) and Vatner et al (https://doi.org/10.1007/s00125-018-4579-1) show that reducing levels of ANGPTL4 and ANGPTL8, respectively, could have the added benefit of improving glucose tolerance. Interestingly, the improvements in glucose tolerance observed in both studies, both done in rodents, were coupled with increased fat mass. These findings suggest that funnelling lipids to adipose tissue and away from ectopic sites could be beneficial and strengthen the argument for pursuing the therapeutic targeting of ANGPTL proteins.

引用

页码：1277 / 1281

页数：5

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