Molecular pathways controlling heart development

被引：371

作者：

Olson, EN ^{[1
]}

Srivastava, D ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT PEDIAT,DIV CARDIOL,DALLAS,TX 75235

来源：

SCIENCE | 1996年 / 272卷 / 5262期

关键词：

D O I：

10.1126/science.272.5262.671

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Heart formation requires complex interactions among cells from multiple embryonic origins. Recent studies have begun to reveal the genetic pathways that control cardiac morphogenesis. Many of the genes within these pathways are conserved across vast phylogenetic distances, which has allowed cardiac development to be dissected in organisms ranging from flies to mammals. Studies of cardiac development have also revealed the molecular defects underlying several congenital cardiac malformations in humans and may ultimately provide opportunities for genetic testing and intervention.

引用

页码：671 / 676

页数：6

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