Molecular Origins of Cancer: Inherited Susceptibility to Common Cancers

被引：366

作者：

Foulkes, William D. ^{[1
,2
,3
,4
,5
]}

机构：

[1] McGill Univ, Program Canc Genet, Gerald Bronfman Ctr Canc Res, Dept Oncol, Montreal, PQ H2W 1S6, Canada

[2] McGill Univ, Dept Oncol, Montreal, PQ H2W 1S6, Canada

[3] McGill Univ, Dept Human Genet, Montreal, PQ H2W 1S6, Canada

[4] McGill Univ, Dept Med, Montreal, PQ H2W 1S6, Canada

[5] McGill Univ, Dept Obstet & Gynecol, Montreal, PQ H2W 1S6, Canada

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 359卷 / 20期

关键词：

D O I：

10.1056/NEJMra0802968

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review deals with germ-line genes that increase susceptibility to five major types of cancer: breast, lung, pancreatic, prostate, and colorectal cancer. Often familial, often appearing at a young age, and often with atypical features, these cancers are caused by mutations in a germ-line gene and frequently with a second mutation in a gene in a somatic cell. The review ends with a discussion of clinical implications, especially for genetic counseling. Copyright © 2008 Massachusetts Medical Society.

引用

页码：2143 / 2153

页数：11

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