Human colonic mucosa possesses a mixed population of 5-HT receptors

被引：35

作者：

Borman, RA ^{[1
]}

Burleigh, DE ^{[1
]}

机构：

[1] UNIV LONDON QUEEN MARY & WESTFIELD COLL,DEPT PHARMACOL,LONDON E1 4NS,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 309卷 / 03期

关键词：

5-HT; (5-hydroxytryptamine; serotonin); 5-HT receptor; secretion; (human); colon; mucosa;

D O I：

10.1016/0014-2999(96)00466-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to characterise the 5-HT receptor(s) mediating secretory responses of isolated human colonic mucosa to 5-HT. Sheets of muscle-stripped mucosa from proximal (ascending) and distal (sigmoid) human colon were set up in Ussing chambers for measurement of short-circuit current (I-SC). Serosal application of 5-HT led to non-neural, concentration-dependent increases in I-SC. Desensitisation to 5-HT was observed with ascending and sigmoid colonic mucosa. Using selective 5-HT antagonists we have shown that 5-HT induces secretion in sigmoid colon via a 5-HT2A receptor. In ascending colon a combination of 5-HT2A and 5-HT4 receptors appears to be involved.

引用

页码：271 / 274

页数：4

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