Therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding

被引：21

作者：

Takatori, Kento ^{[1
]}

Yoshida, Rihito ^{[1
]}

Horai, Aya ^{[1
]}

Satake, Shinya ^{[1
]}

Ose, Takayuki ^{[1
]}

Kitajima, Naoto ^{[1
]}

Yoneda, Shushi ^{[2
]}

Adachi, Kyoichi ^{[3
]}

Amano, Yuji ^{[4
]}

Kinoshita, Yoshikazu ^{[5
]}

机构：

[1] Kasai City Hosp, Dept Internal Med, Kasai City, Hyogo 6752393, Japan

[2] Yoneda Hosp, Dept Internal Med, Kasai, Hyogo, Japan

[3] Shimane Univ, Fac Med, Dept Clin Nursing, Izumo, Shimane, Japan

[4] Int Univ Hlth & Welf, Kaken Hosp, Div Endoscopy, Ichikawa, Chiba, Japan

[5] Shimane Univ, Sch Med, Dept Gastroenterol & Hepatol, Izumo, Shimane, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2013年 / 48卷 / 10期

关键词：

Percutaneous endoscopic gastrostomy; Aspiration pneumonia; Mosapride citrate; Lansoprazole; Esophageal hiatal hernia; PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; PROTON-PUMP INHIBITOR; COMMUNITY-ACQUIRED PNEUMONIA; GASTROESOPHAGEAL-REFLUX; NUTRITIONAL SUPPORT; PLACEMENT; RISK; MANAGEMENT; NUTRIENT; MOTILITY;

D O I：

10.1007/s00535-012-0725-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Aspiration pneumonia is an emerging problem in patients receiving gastrostomy feeding. This study is designed to clarify the therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding. The study subjects were 119 patients with dysphasia who required gastrostomy feeding. They were randomly assigned to the control (without medication), lansoprazole (15 mg, 1/day), and mosapride (5 mg, 3/day) groups. The number of days with fever (a parts per thousand yen37.8 A degrees C), vomiting, and antibiotics administration, as well as the occurrence of pneumonia were investigated during the 6-month observation period. The incidence of pneumonia during the observation period was significantly lower in the mosapride group as compared to the control (7/38 vs. 16/40, p = 0.038) and lansoprazole (vs. 20/41, p = 0.005) groups. The mosapride group also showed a significant decrease in days with fever and antibiotics administration as compared to the other groups. Multivariate analysis revealed that the presence of hiatal hernia was a significant risk factor and administration of mosapride was a significant preventive factor for pneumonia. Mosapride has a preventive effect on occurrence of pneumonia in patients receiving gastrostomy feeding.

引用

页码：1105 / 1110

页数：6

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