Association between Soy Isoflavone Intake and Breast Cancer Risk for Pre- and Post-Menopausal Women: A Meta-Analysis of Epidemiological Studies

被引：107

作者：

Chen, Meinan ^{[1
]}

Rao, Yanhua ^{[3
]}

Zheng, Yi ^{[1
]}

Wei, Shiqing ^{[1
]}

Li, Ye ^{[1
]}

Guo, Tong ^{[2
]}

Yin, Ping ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430074, Peoples R China

[2] WuXiPRA Clin Res Shanghai Co Ltd, Shanghai, Peoples R China

[3] Jiangxia Maternal & Child Hlth Hosp, Wuhan, Peoples R China

来源：

PLOS ONE | 2014年 / 9卷 / 02期

关键词：

FOOD-INTAKE; PHYTOESTROGEN INTAKE; RECEPTOR STATUS; SOYFOOD INTAKE; CHINESE WOMEN; COHORT; ADOLESCENCE; DIAGNOSIS; SURVIVAL; URINARY;

D O I：

10.1371/journal.pone.0089288

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Background: Conclusions drawn from meta-analyses on the association between soy isoflavone intake and breast cancer risk for pre-and post-menopausal women are not fully consistent. These meta-analyses did not explore the influence of different study designs on the pooled results on the basis of distinguishing between pre-and post-menopausal women. Methodology and Principal Findings: We performed a meta-analysis of 35 studies which reported results of association between soy isoflavone intake and breast cancer risk for pre- and/or post-menopausal women, calculated pooled odds ratios and their 95% confidence intervals of pre-and post-menopausal women respectively, and further explored soy isoflavone-breast cancer association on the basis of considering different study regions and designs. Summary results suggested that soy isoflavone intake has a protective effect against breast cancer for both pre- and post-menopausal women. However, they are influenced by study design and region. Pooled ORs of studies carried out in Asian countries suggested that soy isoflavone's protective effect exist in both pre-and post-menopausal women (OR = 0.59, 95% CI: 0.48-0.69 for premenopausal women; OR = 0.59, 95% CI: 0.44-0.74 for postmenopausal women). However, there are some differences between the results pooled from different study designs for women in Asian countries (test for consistency, P = 0.04). Pooled OR of studies on postmenopausal women in Western countries suggested that soy isoflavone intake has a marginally significant protective effect (OR = 0.92; 95% CI: 0.83 similar to 1.00), but further analyses stratifying by study design found no statistically significant association. Conclusions: We meta-analyzed more and newer research results, and separated women according to menopausal status to explore soy isoflavone-breast cancer association. We founded that soy isoflavone intake could lower the risk of breast cancer for both pre-and post-menopausal women in Asian countries. However, for women in Western countries, pre- or postmenopausal, there is no evidence to suggest an association between intake of soy isoflavone and breast cancer.

引用

页数：10

共 27 条

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