Limited variation in the major urinary proteins of laboratory mice

被引:108
作者
Cheetham, Sarah A. [1 ,2 ]
Smith, Abigail L. [3 ,4 ]
Armstrong, Stuart D. [2 ]
Beynon, Robert J. [2 ]
Hurst, Jane L. [1 ]
机构
[1] Univ Liverpool, Dept Vet Preclin Sci, Mammalian Behav & Evolut Grp, Neston CH64 7TE, England
[2] Univ Liverpool, Dept Vet Preclin Sci, Prote & Funct Genom Grp, Liverpool L69 7ZJ, Merseyside, England
[3] Univ Penn, Sch Vet Med, ULAR, Philadelphia, PA 19104 USA
[4] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
基金
英国生物技术与生命科学研究理事会;
关键词
(3-12) mice; Inbreeding; MUPs; Scent communication; Individual recognition; Kin recognition; Mate choice; Laboratory strains; IN-HOUSE MICE; INBRED MOUSE STRAINS; MOLECULAR HETEROGENEITY; INDIVIDUAL-RECOGNITION; GENETIC-BASIS; MUS-MUSCULUS; SCENT; PHEROMONE; SIGNALS; FAMILY;
D O I
10.1016/j.physbeh.2008.10.005
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Individual variation in a specialised set of scent communication proteins, the major urinary proteins (MUPs), provides a genetic identity signature that underlies individual and kin recognition, and the assessment of heterozygosity in wild house mice. Here we examine the extent to which MUP variation is retained among 30 classical strains of laboratory mice from three main lineages (Castle, C57, Swiss). Normal wild-type variation in urinary MUP pattern appears to have been lost at an early stage in the derivation of the classical laboratory strains. All strains from the Castle and Swiss lineages shared the same "individual" MUP pattern, consistent with common ancestry from very few founders, while those from the C57 lineage shared a different pattern. Notably, individual variation in MUP pattern was no greater within the Swiss outbred ICR (CD-1) strain than typical for inbred strains. Total urinary protein concentration varied considerably between even closely related substrains, together with minor variation in the relative amount of each MUP isoform expressed, although the functional significance of such quantitative variation in MUP expression has yet to be established, Expression was 2-8 fold higher among males, while a MUP expressed by most male but not female wild mice was expressed by C57 males but variably among Castle and Swiss males and occasionally by females in some strains. The lack of normal variation in MUP patterns within and between strains has important implications for the use of laboratory mice in behavioural or neurophysiological research investigating social recognition or mate choice. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:253 / 261
页数:9
相关论文
共 48 条
[1]   Structural and functional differences in isoforms of mouse major urinary proteins: a male-specific protein that preferentially binds a male pheromone [J].
Armstrong, SD ;
Robertson, DHL ;
Cheetham, SA ;
Hurst, JL ;
Beynon, RJ .
BIOCHEMICAL JOURNAL, 2005, 391 :343-350
[2]   PHEROMONE BINDING-PROTEINS OF THE MOUSE, MUS-MUSCULUS [J].
BACCHINI, A ;
GAETANI, E ;
CAVAGGIONI, A .
EXPERIENTIA, 1992, 48 (04) :419-421
[3]   Genealogies of mouse inbred strains [J].
Beck, JA ;
Lloyd, S ;
Hafezparast, M ;
Lennon-Pierce, M ;
Eppig, JT ;
Festing, MFW ;
Fisher, EMC .
NATURE GENETICS, 2000, 24 (01) :23-+
[4]   Urinary proteins and the modulation of chemical scents in mice and rats [J].
Beynon, RJ ;
Hurst, JL .
PEPTIDES, 2004, 25 (09) :1553-1563
[5]   Urinary lipocalins in rodenta: is there a generic model? [J].
Beynon, Robert J. ;
Hurst, Jane L. ;
Mirton, Michael J. ;
Robertson, Duncan H. L. ;
Armstrong, Stuart D. ;
Cheetham, Sarah A. ;
Simpson, Deborah ;
MacNicoll, Alan ;
Humphries, Richard E. .
CHEMICAL SIGNALS IN VERTEBRATES 11, 2008, 11 :37-+
[6]   THE EVOLUTION OF HOUSE MICE [J].
BOURSOT, P ;
AUFFRAY, JC ;
BRITTONDAVIDIAN, J ;
BONHOMME, F .
ANNUAL REVIEW OF ECOLOGY AND SYSTEMATICS, 1993, 24 :119-152
[7]   More to pheromones than meets the nose [J].
Broad, Kevin D. ;
Keverne, Eric B. .
NATURE NEUROSCIENCE, 2008, 11 (02) :128-129
[8]   WHAT IS THE ROLE OF THE IMMUNE-SYSTEM IN DETERMINING INDIVIDUALLY DISTINCT BODY ODORS [J].
BROWN, RE .
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1995, 17 (08) :655-661
[9]   Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues [J].
Carroll, LS ;
Penn, DJ ;
Potts, WK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2187-2192
[10]   Identification of protein pheromones that promote aggressive behaviour [J].
Chamero, Pablo ;
Marton, Tobias F. ;
Logan, Darren W. ;
Flanagan, Kelly ;
Cruz, Jason R. ;
Saghatelian, Alan ;
Cravatt, Benjamin F. ;
Stowers, Lisa .
NATURE, 2007, 450 (7171) :899-U23