Apoptosis in animal models of virus-induced disease

被引：160

作者：

Clarke, Penny ^{[1
]}

Tyler, Kenneth L. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Colorado, Denver Hlth Sci Programs, Dept Neurol, Aurora, CO 80045 USA

[2] Univ Colorado, Denver Hlth Sci Programs, Dept Immunol, Aurora, CO 80045 USA

[3] Univ Colorado, Denver Hlth Sci Programs, Dept Med, Aurora, CO 80045 USA

[4] Univ Colorado, Denver Hlth Sci Programs, Dept Microbiol, Aurora, CO 80045 USA

[5] Denver Vet Adm, Denver, CO 80220 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; WEST-NILE-VIRUS; HERPES-SIMPLEX-VIRUS; THEILERS MURINE ENCEPHALOMYELITIS; COXSACKIEVIRUS B3-INDUCED MYOCARDITIS; CHRONIC HEPATITIS-C; N-TERMINAL KINASE; MURRAY VALLEY ENCEPHALITIS; REOVIRUS-INDUCED APOPTOSIS; JUN NH2-TERMINAL KINASE;

D O I：

10.1038/nrmicro2071

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Apoptosis is associated with virus-induced human diseases of the central nervous system, heart and liver, and causes substantial morbidity and mortality. Although virus-induced apoptosis is well characterized in individual cells in cell culture, virus-induced apoptosis in vivo and the role of apoptosis in virus-induced disease is not well established. This Review focuses on animal models of virus-induced diseases of the central nervous system, heart and liver that provide insights into the role of apoptosis in pathogenesis, the pathways involved and the potential therapeutic implications.

引用

页码：144 / 155

页数：12

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