Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

被引：174

作者：

Barter, M. J. ^{[1
]}

Bui, C. ^{[1
]}

Young, D. A. ^{[1
]}

机构：

[1] Newcastle Univ, Musculoskeletal Res Grp, Inst Cellular Med, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

OSTEOARTHRITIS AND CARTILAGE | 2012年 / 20卷 / 05期

关键词：

Epigenetics; DNA methylation; Chromatin; microRNAs; Cartilage; HUMAN ARTICULAR CHONDROCYTES; METALLOPROTEINASE GENE-EXPRESSION; MESENCHYMAL STEM-CELLS; II COLLAGEN EXPRESSION; DEACETYLASE INHIBITORS; RHEUMATOID-ARTHRITIS; S-ADENOSYLMETHIONINE; DOWN-REGULATION; CPG SITES; CHROMATIN MODIFICATIONS;

D O I：

10.1016/j.joca.2011.12.012

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Osteoarthritis (OA) is a complex multifactorial disease with a strong genetic component. Several studies have suggested or identified epigenetic events that may play a role in OA progression and the gene expression changes observed in diseased cartilage. The aim of this review is to inform about current research in epigenetics and epigenetics in OA. Epigenetic mechanisms include DNA methylation, histone modifications, and microRNAs. Collectively, these enable the cell to respond quickly to environmental changes and can be inherited during cell division. However, aberrant epigenetic modifications are associated with a number of pathological conditions, including OA. Advancements in epigenetic research suggests that global analysis of such modifications in OA are now possible, however, with the exception of microRNAs, it will be a significant challenge to demonstrate how such events impact on the disease. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：339 / 349

页数：11

共 111 条

[1]

Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro [J].