Design and synthesis of ribonucleic guanidine: A polycationic analog of RNA

被引：36

作者：

Dempcy, RO

Luo, J

Bruice, TC

机构：

[1] Department of Chemistry, University of California, Santa Barbara

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 09期

关键词：

antisense; antigene; triple helix;

D O I：

10.1073/pnas.93.9.4326

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)(9)U . r(Ag)(9)A . r(Up)(9)U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)(3)A].

引用

页码：4326 / 4330

页数：5

共 9 条

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