A general synthesis of homochiral β-hydroxy N-acetylcysteamine thioesters

被引：8

作者：

Le Sann, C

Simpson, TJ

Smith, DI

Watts, P

Willis, CL

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Alnwich Res Ctr, Sanofi Res, Alnwich NE66 2JH, Northd, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(99)00657-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and efficient route for the enantioselective synthesis of functionalised B-hydroxy N-acetyicysteamine thioesters is described. The route allows the facile incorporation of vicinal C-13 labelling to produce intermediates required for biosynthetic studies on a wide range of polyketide metabolites, e.g. 6-MSA, monocerin, colletodiol and strobilurins. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：4093 / 4096

页数：4

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