Salviae radix root extract inhibits immunoglobulin E-mediated allergic reaction

被引：14

作者：

Kim, HM ^{[1
]}

Lee, EH

Lee, JH

Jung, JA

Kim, JJ

机构：

[1] Wonkwang Univ, Dept Oriental Pharm, Coll Pharm, Iksan 570749, Chonbuk, South Korea

[2] Kwangyang Coll, Dept Dent Hyg, Kwangyang 545800, Chonnam, South Korea

[3] Wonkwang Univ, Sch Med, Dept Anat, Iksan 570749, Chonbuk, South Korea

来源：

GENERAL PHARMACOLOGY | 1999年 / 32卷 / 05期

关键词：

Salviae radix; immediate allergic reaction; anti-dinitrophenyl IgE; histamine; compound; 48/80; cAMP;

D O I：

10.1016/S0306-3623(98)00226-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effects of the aqueous extract of Salviae radix root (SRRAE) on immediate allergic reactions. SRRAE inhibited by 72.7% passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) immunoglobulin E (IgE). SRRAE dose dependently inhibited histamine release and tumor necrosis factor-alpha production from the rat peritoneal mast cells (RPMCs) by anti-DNP IgE. However, SRRAE showed no significant inhibitory effect on compound 48/80-induced systemic allergic reaction and histamine release from RPMCs. The level of cAMP in RPMCs, when SRRAE was added, significantly increased compared with that of a normal control. These results indicate that SRRAE may contain compounds with actions that inhibit anti-DNP IgE-induced mast cell degranulation in rats. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：603 / 608

页数：6

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