Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease

被引:87
作者
Browning, Jeffrey L. [1 ]
机构
[1] Biogen Idec Inc, Dept Immunobiol, Cambridge, MA 02142 USA
关键词
cytokines; lymph nodes; cell trafficking; arthritis; tertiary lymphoid tissues;
D O I
10.1111/j.1600-065X.2008.00633.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The lymphotoxin (LT) system is part of the tumor necrosis factor family and is required for lymph node development. It has provided a wonderful tool for the dissection of processes critical not only for lymphoid organ development but also the maintenance of the adult immune architecture and the formation of ectopic organized lymphoid tissues in chronically inflamed sites. A soluble lymphotoxin-beta receptor-immunoglobulin (LT beta R-Ig) fusion protein can block this pathway and is currently being tested in the treatment of autoimmune disease. This review focuses on the immunological consequences of combined LT and LIGHT inhibition with LT beta R-Ig administration as distinct from the developmental biology.
引用
收藏
页码:202 / 220
页数:19
相关论文
共 196 条
[1]   Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease [J].
Adams, DH ;
Eksteen, B .
NATURE REVIEWS IMMUNOLOGY, 2006, 6 (03) :244-251
[2]   Germinal-center organization and cellular dynamics [J].
Allen, Christopher D. C. ;
Okada, Takaharu ;
Cyster, Jason G. .
IMMUNITY, 2007, 27 (02) :190-202
[3]   Lymphoid neogenesis in chronic inflammatory diseases [J].
Aloisi, F ;
Pujol-Borrell, R .
NATURE REVIEWS IMMUNOLOGY, 2006, 6 (03) :205-217
[4]   Lymphtoxin β receptor-Ig protects from T-cell-mediated liver injury in mice through blocking LIGHT/HVEM signaling [J].
An, Mao-Mao ;
Fan, Ke-Xing ;
Cao, Yong-Bing ;
Shen, Hui ;
Zhang, Jun-Dong ;
Lu, Lei ;
Gao, Ping-Hui ;
Jiang, Yuan-Ying .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (10) :2025-2030
[5]   Lymphtoxin β receptor-Ig ameliorates TNBS-induced colitis via blocking LIGHT/HVEM signaling [J].
An, MM ;
Fan, KX ;
Zhang, JD ;
Li, HJ ;
Song, SC ;
Liu, BG ;
Gao, PH ;
Zhou, Q ;
Jiang, YY .
PHARMACOLOGICAL RESEARCH, 2005, 52 (03) :234-244
[6]   Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis [J].
Anand, S ;
Wang, P ;
Yoshimura, K ;
Choi, IH ;
Hilliard, A ;
Chen, YH ;
Wang, CR ;
Schulick, R ;
Flies, AS ;
Flies, DB ;
Zhu, GF ;
Xu, YH ;
Pardoll, DM ;
Chen, LP ;
Tamada, K .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (04) :1045-1051
[7]   Contribution of the lymphotoxin β receptor to liver regeneration [J].
Anders, RA ;
Subudhi, SK ;
Wang, J ;
Pfeffer, K ;
Fu, YX .
JOURNAL OF IMMUNOLOGY, 2005, 175 (02) :1295-1300
[8]   B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization [J].
Angeli, V ;
Ginhoux, F ;
Llodrá, J ;
Quemeneur, L ;
Frenette, PS ;
Skobe, M ;
Jessberger, R ;
Merad, M ;
Randolph, GJ .
IMMUNITY, 2006, 24 (02) :203-215
[9]   Cutting edge: Anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid germinal centers and follicular dendritic cell networks [J].
Anolik, Jennifer H. ;
Ravikumar, Rajan ;
Barnard, Jennifer ;
Owen, Teresa ;
Almudevar, Anthony ;
Milner, Eric C. B. ;
Miller, Chase H. ;
Dutcher, Paul O. ;
Hadley, James A. ;
Sanz, Inaki .
JOURNAL OF IMMUNOLOGY, 2008, 180 (02) :688-692
[10]   A chemokine-driven positive feedback loop organizes lymphoid follicles [J].
Ansel, KM ;
Ngo, VN ;
Hyman, PL ;
Luther, SA ;
Förster, R ;
Sedgwick, JD ;
Browning, JL ;
Lipp, M ;
Cyster, JG .
NATURE, 2000, 406 (6793) :309-314