Cancer - DNA damage enables p73

被引：66

作者：

White, E

Prives, C

机构：

[1] Canc Inst New Jersey, Dept Mol Biol & Biochem, Ctr Adv Biotechnol & Med, Howard Hughes Med Inst, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Piscataway, NJ 08854 USA

[3] Columbia Univ, Dept Biol Sci, Sherman Fairchild Ctr Life Sci, New York, NY 10027 USA

来源：

NATURE | 1999年 / 399卷 / 6738期

关键词：

D O I：

10.1038/21539

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The'guardian of the genome', p53, is the best-known tumour-suppressor gene. Two other proteins — p63 and p73 — have similar sequences and properties to p53. But p53 is the only one to be induced by DNA damage. Or at least it was. A new study shows that, in fact, p73 is also induced by DNA damage via the non-receptor tyrosine kinase c-Abl.

引用

页码：734 / +

页数：3

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