Naturally occurring antibodies to cholesterol: a new theory of LDL cholesterol metabolism

被引：41

作者：

Alving, CR ^{[1
]}

Wassef, NM ^{[1
]}

机构：

[1] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Membrane Biochem, Washington, DC 20307 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 08期

关键词：

D O I：

10.1016/S0167-5699(99)01496-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although low-density lipoprotein (LDL) receptors regulate the disposition of two-thirds of circulating serum LDL cholesterol, non-LDL receptor mechanisms account for removal of one-third. Here, Carl Alving and Nabila Wassef propose that naturally occurring antibodies to cholesterol in normal human plasma also contribute to LDL cholesterol turnover by opsonizing LDL and other lipoproteins containing 'bad' cholesterol for removal by complement receptors.

引用

页码：362 / 366

页数：5

共 29 条

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