Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis

被引：27

作者：

Greve, B

Magnusson, CGM

Melms, A

Weissert, R

机构：

[1] Univ Tubingen, Dept Neurol, D-72076 Tubingen, Germany

[2] Karolinska Hosp & Inst, Unit Clin Immunol & Allergy, Dept Med, S-17176 Stockholm, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 121卷 / 1-2期

关键词：

multiple sclerosis; demyelinating disease; B cells; isotypes; IgE;

D O I：

10.1016/S0165-5728(01)00436-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IgG, its subclasses and IgE concentrations were measured in cerebrospinal fluid (CSF) and serum of multiple sclerosis (MS) patients and matched controls as surrogate markers for type 1 and type 2 immunity. lgE indices were significantly reduced in MS patients compared to controls. In contrast, IgGI was elevated in CSF of MS patients and elevated indices indicated intrathecal synthesis. Because isotype switching to IgE and IgG4 is driven by type 2 immunity and occurrence of IgG1 has previously been found in type I inimunity-dominated diseases, the results underscore a role of type I immunity in MS. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：120 / 125

页数：6

共 43 条

[1] Functional diversity of helper T lymphocytes
Abbas, AK
Murphy, KM
Sher, A
[J]. NATURE, 1996, 383 (6603) : 787 - 793
[2] CCR5+ and CXCR3+ T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions
Balashov, KE
Rottman, JB
Weiner, HL
Hancock, WW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) : 6873 - 6878
[3] STANDARDIZATION AND STABILITY OF IMMUNOGLOBULIN E (IGE)
BAZARAL, M
HAMBURGER, RN
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1972, 49 (03) : 189 - +
[4] FORMULAS FOR THE QUANTITATION OF INTRATHECAL IGG PRODUCTION - THEIR VALIDITY IN THE PRESENCE OF BLOOD-BRAIN-BARRIER DAMAGE AND THEIR UTILITY IN MULTIPLE-SCLEROSIS
BLENNOW, K
FREDMAN, P
WALLIN, A
GOTTFRIES, CG
FREY, H
PIRTTILA, T
SKOOG, I
WIKKELSO, C
SVENNERHOLM, L
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1994, 121 (01) : 90 - 96
[5] Bonifacio E, 1999, J IMMUNOL, V163, P525
[6] RELATIONSHIPS BETWEEN ABNORMAL IGG INDEX, OLIGOCLONAL BANDS, ACUTE PHASE REACTANTS AND SOME CLINICAL DATA IN MULTIPLE-SCLEROSIS
CHRISTENSEN, O
CLAUSEN, J
FOG, T
[J]. JOURNAL OF NEUROLOGY, 1978, 218 (04) : 237 - 244
[7] Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy
Comabella, M
Balashov, K
Issazadeh, S
Smith, D
Weiner, HL
Khoury, SJ
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (04) : 671 - 678
[8] IMMUNOCHEMICAL ESTIMATION OF IGG AND ALBUMIN IN CEREBROSPINAL-FLUID
DELPECH, B
LICHTBLA.E
[J]. CLINICA CHIMICA ACTA, 1972, 37 (NMAR) : 15 - &
[9] Falcone M, 1998, J IMMUNOL, V160, P4822
[10] Ferrante P, 1998, J IMMUNOL, V160, P1514

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