The role of metal ions in amyloid formation: general principles from model peptides

被引：47

作者：

Alies, Bruno ^{[1
,2
]}

Hureau, Christelle ^{[1
,2
]}

Faller, Peter ^{[1
,2
]}

机构：

[1] CNRS, LCC, F-31077 Toulouse 4, France

[2] Univ Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France

来源：

METALLOMICS | 2013年 / 5卷 / 03期

关键词：

ALZHEIMERS-DISEASE; BETA PEPTIDES; A-BETA; NEURODEGENERATIVE DISEASES; PRECURSOR PROTEIN; PRION DISEASES; BINDING; COORDINATION; ZINC; KINETICS;

D O I：

10.1039/c3mt20219d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The mechanistic understanding of peptide self-assembly mediated by metal ions into amyloids or other structures has gained a lot of interest, mainly due to their importance in several neurodegenerative diseases. The use of short, easy-to-handle peptides has contributed to a better knowledge of structures and mechanisms that are also relevant for the native and longer peptides involved in the neurodegenerative diseases. Here, we review the results obtained with such "model systems" with the aim to identify and discuss fundamental parameters determining the self-aggregation with a special focus on the role of metal ions in this process.

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页码：183 / 192

页数：10

相关论文

共 45 条

[1]

Insights into the Mechanisms of Amyloid Formation of ZnII-Ab11-28: pH-Dependent Zinc Coordination and Overall Charge as Key Parameters for Kinetics and the Structure of ZnII-Ab11-28 Aggregates [J].

Alies, Bruno ;

LaPenna, Giovanni ;

Sayen, Stephanie ;

Guillon, Emmanuel ;

Hureau, Christelle ;

Faller, Peter .

INORGANIC CHEMISTRY, 2012, 51 (14) :7897-7902

[2]

Dynamics of ZnII Binding as a Key Feature in the Formation of Amyloid Fibrils by Aβ11-28 [J].

Alies, Bruno ;

Solari, Pier-Lorenzo ;

Hureau, Christelle ;

Faller, Peter .

INORGANIC CHEMISTRY, 2012, 51 (01) :701-708

[3]

Zinc(II) modulates specifically amyloid formation and structure in model peptides [J].

Alies, Bruno ;

Pradines, Vincent ;

Llorens-Alliot, Isabelle ;

Sayen, Stephanie ;

Guillon, Emmanuel ;

Hureau, Christelle ;

Faller, Peter .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2011, 16 (02) :333-340

[4]

Metastability of Native Proteins and the Phenomenon of Amyloid Formation [J].

Baldwin, Andrew J. ;

Knowles, Tuomas P. J. ;

Tartaglia, Gian Gaetano ;

Fitzpatrick, Anthony W. ;

Devlin, Glyn L. ;

Shammas, Sarah Lucy ;

Waudby, Christopher A. ;

Mossuto, Maria F. ;

Meehan, Sarah ;

Gras, Sally L. ;

Christodoulou, John ;

Anthony-Cahill, Spencer J. ;

Barker, Paul D. ;

Vendruscolo, Michele ;

Dobson, Christopher M. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (36) :14160-14163

[5]

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective [J].

Brender, Jeffrey R. ;

Salamekh, Samer ;

Ramamoorthy, Ayyalusamy .

ACCOUNTS OF CHEMICAL RESEARCH, 2012, 45 (03) :454-462

[6]

Role of Zinc in Human Islet Amyloid Polypeptide Aggregation [J].

Brender, Jeffrey R. ;

Hartman, Kevin ;

Nanga, Ravi Prakash Reddy ;

Popovych, Nataliya ;

Bea, Roberto de la Salud ;

Vivekanandan, Subramanian ;

Marsh, E. Neil G. ;

Ramamoorthy, Ayyalusamy .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (26) :8973-8983

[7]

Amyloids: Not only pathological agents but also ordered nanomaterials [J].

Cherny, Izhack ;

Gazit, Ehud .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (22) :4062-4069

[8]

Protein misfolding, functional amyloid, and human disease [J].

Chiti, Fabrizio ;

Dobson, Christopher M. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :333-366

[9]

Misfolded proteins in Alzheimer's disease and type II diabetes [J].

DeToma, Alaina S. ;

Salamekh, Samer ;

Ramamoorthy, Ayyalusamy ;

Lim, Mi Hee .

CHEMICAL SOCIETY REVIEWS, 2012, 41 (02) :608-621

[10]

Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity [J].

Dong, Jijun ;

Canfield, Jeffrey M. ;

Mehta, Anil K. ;

Shokes, Jacob E. ;

Tian, Bo ;

Childers, W. Seth ;

Simmons, James A. ;

Mao, Zixu ;

Scott, Robert A. ;

Warncke, Kurt ;

Lynn, David G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (33) :13313-13318

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