Structure and function of dendritic spines

被引：882

作者：

Nimchinsky, EA ^{[1
]}

Sabatini, BL ^{[1
]}

Svoboda, K ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 2002年 / 64卷

关键词：

synapse; NMDA receptor; voltage-sensitive calcium channel; fragile X; calcium;

D O I：

10.1146/annurev.physiol.64.081501.160008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Spines are neuronal protrusions, each of which receives input typically from one excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling systems essential for synaptic function and plasticity. Numerous brain disorders are associated with abnormal dendritic spines. Spine formation, plasticity, and maintenance depend on synaptic activity and can be modulated by sensory experience. Studies of compartmentalization have shown that spines serve primarily as biochemical, rather than electrical, compartments. In particular, recent work has highlighted that spines are highly specialized compartments for rapid large-amplitude Ca2+ signals underlying the induction of synaptic plasticity.

引用

页码：313 / 353

页数：43

共 230 条

[1] QUANTITATIVE ULTRASTRUCTURAL-CHANGES IN RAT CORTICAL SYNAPSES DURING EARLY-ADULTHOOD AND LATE-ADULTHOOD [J].

ADAMS, I ;

JONES, DG .

BRAIN RESEARCH, 1982, 239 (02) :349-363

[2] RANGE OF MESSENGER ACTION OF CALCIUM-ION AND INOSITOL 1,4,5-TRISPHOSPHATE [J].

ALLBRITTON, NL ;

MEYER, T ;

STRYER, L .

SCIENCE, 1992, 258 (5089) :1812-1815

[3] ACTIVITY-DEPENDENT ACCUMULATION OF CALCIUM IN PURKINJE-CELL DENDRITIC SPINES [J].

ANDREWS, SB ;

LEAPMAN, RD ;

LANDIS, DMD ;

REESE, TS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1682-1685

[4] ACTIVITY-DEPENDENT REGULATION OF DENDRITIC SPINE DENSITY ON CORTICAL PYRAMIDAL NEURONS IN ORGANOTYPIC SLICE CULTURES [J].

ANNIS, CM ;

ODOWD, DK ;

ROBERTSON, RT .

JOURNAL OF NEUROBIOLOGY, 1994, 25 (12) :1483-1493

[5]

[Anonymous], 1891, La Cellule

[6] MOBILITY MEASUREMENT BY ANALYSIS OF FLUORESCENCE PHOTOBLEACHING RECOVERY KINETICS [J].

AXELROD, D ;

KOPPEL, DE ;

SCHLESSINGER, J ;

ELSON, E ;

WEBB, WW .

BIOPHYSICAL JOURNAL, 1976, 16 (09) :1055-1069

[7] EXPERIMENTAL MODIFICATION OF CEREBELLAR DEVELOPMENT IN TISSUE-CULTURE - X-IRRADIATION INDUCES GRANULAR DEGENERATION AND UNATTACHED PURKINJE-CELL DENDRITIC SPINES [J].

BALOYANNIS, SJ ;

KIM, SU .

NEUROSCIENCE LETTERS, 1979, 12 (2-3) :283-288

[8] SYNAPTIC CURRENTS EVOKED IN PURKINJE-CELLS BY STIMULATING INDIVIDUAL GRANULE CELLS [J].

BARBOUR, B .

NEURON, 1993, 11 (04) :759-769

[9] PROLONGED PRESENCE OF GLUTAMATE DURING EXCITATORY SYNAPTIC TRANSMISSION TO CEREBELLAR PURKINJE-CELLS [J].

BARBOUR, B ;

KELLER, BU ;

LLANO, I ;

MARTY, A .

NEURON, 1994, 12 (06) :1331-1343

[10] QUANTITATIVE DISTRIBUTION OF GABA-IMMUNOPOSITIVE AND GABA-IMMUNONEGATIVE NEURONS AND SYNAPSES IN THE MONKEY STRIATE CORTEX (AREA-17) [J].

BEAULIEU, C ;

KISVARDAY, Z ;

SOMOGYI, P ;

CYNADER, M ;

COWEY, A .

CEREBRAL CORTEX, 1992, 2 (04) :295-309

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