DNA double-strand break repair functions defend against parvovirus infection

被引：12

作者：

Tauer, TJ

Schneiderman, MH

Vishwanatha, JK

Rhode, SL

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT BIOCHEM & MOL BIOL,OMAHA,NE 68198

[2] UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL,OMAHA,NE 68198

[3] UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC & ALLIED DIS,OMAHA,NE 68198

[4] UNIV NEBRASKA,MED CTR,CANC RES LABS,DEPT RADIOL,OMAHA,NE 68198

[5] UNIV NEBRASKA,MED CTR,CANC RES LABS,DEPT RADIAT ONCOL,OMAHA,NE 68198

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 09期

关键词：

D O I：

10.1128/JVI.70.9.6446-6449.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We measured parvovirus replication and sensitivity to X-ray damage in nine CHO fell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.

引用

页码：6446 / 6449

页数：4

共 24 条

[1] REPLICATION OF MINUTE VIRUS OF MICE IN CHINESE-HAMSTER OVARY FIBROBLASTS [J].